Cerebral blood flow and behavioural effects of caffeine in habitual and non-habitual consumers of caffeine: A near infrared spectroscopy study
Cerebral blood flow and behavioural effects of caffeine in habitual and non-habitual consumers of caffeine: A near infrared spectroscopy study
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DOI：
10.1016/j.biopsycho.2010.12.010
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发表时间：
2011-03-01
影响因子：
2.6
通讯作者：
Haskell, Crystal F.
中科院分区：
文献类型：
--
作者：
Kennedy, David O.;Haskell, Crystal F.
咖啡因已被证明可以调节脑血流量，但几乎没有证据表明咖啡因在习惯使用后对这些作用具有耐受性。然而，之前的研究关注的咖啡因含量远高于饮食中的咖啡因含量，并将高咖啡因消费者与低咖啡因消费者而不是“非消费者”进行比较。目前的安慰剂对照双盲平衡交叉研究采用近红外光谱来监测休息时和完成激活前额皮质任务期间的前额叶大脑血流动力学。 20 名健康的年轻习惯性和非习惯性咖啡因消费者接受了 75 毫克咖啡因或安慰剂。咖啡因显着降低脑血流量，但这与摄入状态存在显着的相互作用，在习惯性饮用者中没有显示出显着的效果，而在非习惯性饮用者中则显示出夸大的效果。这些发现表明，单份膳食中通常存在的咖啡因水平能够调节脑血流量，但这些作用会受到耐受性的影响。 (C) 2011 Elsevier B.V. 保留所有权利。
Caffeine has been shown to modulate cerebral blood flow, with little evidence of tolerance to these effects following habitual use. However, previous studies have focused on caffeine levels much higher than those found in dietary servings and have compared high caffeine consumers with low consumers rather than 'non-consumers'. The current placebo-controlled double-blind, balanced-crossover study employed near infrared spectroscopy to monitor pre-frontal cerebral-haemodynamics at rest and during completion of tasks that activate the pre-frontal cortex. Twenty healthy young habitual and non-habitual consumers of caffeine received 75 mg caffeine or placebo. Caffeine significantly decreased cerebral blood flow but this was subject to a significant interaction with consumption status, with no significant effect being shown in habitual consumers and an exaggerated effect in non-habitual consumers. These findings suggest that caffeine, at levels typically found in a single dietary serving, is able to modulate cerebral blood flow but these effects are subject to tolerance. (C) 2011 Elsevier B.V. All rights reserved.