Impaired acquisition of skilled behavior in rotarod task by moderate depletion of striatal doparnine in a pre-symptomatic stage model of Parkinson's disease
Impaired acquisition of skilled behavior in rotarod task by moderate depletion of striatal doparnine in a pre-symptomatic stage model of Parkinson's disease
复制标题
DOI：
10.1016/j.neures.2004.12.006
复制
发表时间：
2005-03-01
影响因子：
2.9
通讯作者：
Saji, M
中科院分区：
文献类型：
--
作者：
Ogura, T;Ogata, M;Saji, M
鉴于最近的研究结果表明，黑质纹状体多巴胺（DA）系统在运动控制和习惯和技能的获得中发挥作用，我们假设，纹状体为基础的功能，获得熟练的行为可能更容易受到多巴胺耗尽比运动控制。为了验证这一假设，我们调查了是否受损收购的熟练行为发生在症状前阶段模型帕金森病（PD）。通过使用微透析方法和6-OHDA-技术破坏多巴胺神经元，我们证实了用6-OHDA单侧部分损伤黑质多巴胺细胞的大鼠适用于帕金森病的症状前阶段模型。该模型中的大鼠表现出纹状体多巴胺释放功能的中度破坏和相对完整的运动功能。在转棒试验中，6-OHDA双侧黑质多巴胺细胞部分损伤的大鼠出现技能行为的获得受损。这些大鼠表现出完整的一般运动功能，如自发活动，调整步骤，平衡功能和肌肉力量。基于这些结果，我们得出结论，纹状体为基础的功能收购熟练的行为或感觉运动学习可能更容易受到多巴胺耗尽比运动控制。(C)2004年Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
In view of recent findings that suggest that the nigrostriatal dopamine (DA) system plays a role in motor control and the acquisition of habits and skills, we hypothesized that the striatum-based function underlying the acquisition of skilled behaviors might be more vulnerable to dopamine depletion than the motor control. To test this hypothesis, we investigated whether impaired acquisition of skilled behaviors occurs in a pre-symptomatic stage model of Parkinson's disease (PD). By using the microdialysis method and the 6-OHDA-technique to destroy dopamine neurons, we confirmed that rats with unilateral partial lesions of the nigral dopamine cells by 6-OHDA are suitable for a presymptomatic stage model of Parkinson's disease. The rats in this model exhibited moderate disruption of striatal dopamine release function and relatively intact motor functions. In a rotarod test, the impaired acquisition of skilled behavior occurred in rats with bilateral partial lesions of the nigral dopamine cells by 6-OHDA. These rats displayed intact general motor functions, such as locomotor activity, adjusting steps, equilibrium function and muscle strength. Based on these results, we concluded that the striatium-based function underlying the acquisition of skilled behaviors or sensorimotor learning may be more vulnerable to dopamine depletion than the motor control. (C) 2004 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.