INTRACELLULAR HETEROGENEITY IN MITOCHONDRIAL-MEMBRANE POTENTIALS REVEALED BY A J-AGGREGATE-FORMING LIPOPHILIC CATION JC-1
INTRACELLULAR HETEROGENEITY IN MITOCHONDRIAL-MEMBRANE POTENTIALS REVEALED BY A J-AGGREGATE-FORMING LIPOPHILIC CATION JC-1
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DOI：
10.1073/pnas.88.9.3671
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发表时间：
1991-05-01
影响因子：
11.1
通讯作者：
CHEN, LB
中科院分区：
文献类型：
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作者：
SMILEY, ST;REERS, M;CHEN, LB
通过使用电位依赖性 J-聚集体形成的离域亲脂性阳离子 5,5',6,6'-四氯-1,1',3,3'-四乙基苯并咪唑并羰花青碘化物 (JC-1)，我们发现活细胞中线粒体的膜电位可能是异质的。值得注意的是，即使在长的连续线粒体内，膜电位的区域异质性似乎也是可能的。
By using a potential-dependent J-aggregate-forming delocalized lipophilic cation, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide (JC-1), we find that membrane potentials across mitochondria in a living cell can be heterogeneous. Remarkably, even within a long contiguous mitochondrion, regional heterogeneity in membrane potentials appears to be possible.