CARDIAC RESPONSES ELICITED BY PEPTIDES ADMINISTERED TO CANINE INTRINSIC CARDIAC NEURONS
CARDIAC RESPONSES ELICITED BY PEPTIDES ADMINISTERED TO CANINE INTRINSIC CARDIAC NEURONS
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DOI：
10.1016/0196-9781(90)90191-7
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发表时间：
1990-07-01
期刊：
影响因子：
3
通讯作者：
BUTLER, CK
中科院分区：
文献类型：
--
作者：
ARMOUR, JA;YUAN, BX;BUTLER, CK
为了研究多肽对心脏内禀神经元的影响，将P物质、缓激肽、催产素、降钙素基因相关肽、心房利钠肽和血管活性肠肽注入犬心房或心室神经节丛。当P物质注入右心房或颅内室神经节丛心率时，心房力和心室心内压升高。将等量的生理盐水（即肽载体）注射到这些神经节丛中，没有发生心脏变化。缓激肽注入心房或心室神经节丛心率时，心房力和心室力均增强。约50%和50%的抑郁反应被诱导。50%的动物。当催产素被注射到右心房腹侧神经节丛时，10只狗中有5只的心率和心房力都降低了。左心房和左心室神经节丛注射催产素后，心脏无明显变化。将降钙素基因相关肽、心房利钠肽或血管活性肠肽注入心房或心室神经节丛均无反应。急性心脏去中心化后，反复给药P物质、缓激肽或催产素都没有引起明显的反应，这意味着与中枢神经系统神经元的连接对于引起一致的反应是必要的。由此得出结论，P物质、促动素和催产素可以影响心脏上的神经元，从而改变心脏动力学，这些不同的肽引起不同的心脏反应。
In order to study the effects of peptides on intrinsic cardiac neurons, substance P, bradykinin, oxytocin, calcitonin gene related peptide, atrial natriuretic peptide and vasoactive intestinal peptide were administered into canine atrial or ventricular ganglionated plexi. When substance P was injected into right atrial or cranial medial ventricular ganglionated plexi heart rate, atrial force and ventricular intramyocardial pressures were augmented. No cardiac changes occurred when similar volumes of saline (i.e., peptide vehicle) were injected into these ganglionated plexi. When bradykinin was injected into atrial or ventricular ganglionated plexi heart rate, atrial force and ventricular force were augmented in .apprx.50% and depressor responses were elicited in .apprx.50% of these animals. When oxytocin was injected into right atrial ventral glanglionated plexi heart rate and atrial forces were reduced in five of ten dogs studied. No cardiac changes occurred when oxytocin was injected into left atrial or ventricular ganglionated plexi. No respones were elicited when calcitonin gene related peptide, atrial natriuretic peptide or vasoactive intestinal peptide was administered into atrial or ventricular ganglionated plexi. Following acute decentralization of the heart, no significant responses were elicited by repeat administrations of substance P, bradykinin or oxytocin, implying that connectivity with central nervous system neurons was necessary for consistent responses to be elicited. It is conclued that substance P, brakykinin and oxytocin can affect neurons on the heart such that cardiodynamics are modified, these different peptides eliciting different cardiac responses.