Relationship between diseases accompanied by tissue destruction and granulocytes with surface adrenergic receptors
Relationship between diseases accompanied by tissue destruction and granulocytes with surface adrenergic receptors
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DOI：
10.1007/bf02697370
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发表时间：
2007-01-01
影响因子：
4.4
通讯作者：
Kanda, Yasuhiro
中科院分区：
文献类型：
--
作者：
Abo, Toru;Kawamura, Toshihiko;Kanda, Yasuhiro
众所周知，生理现象和某些疾病，包括新生儿粒细胞增多症、年龄相关性粒细胞增多症、牙周炎、胰腺炎、克罗恩病、溃疡性结肠炎、痔疮、子宫内膜异位症和NSAID肠炎，都伴随着组织破坏和粒细胞增多症。我们研究了什么是连接组织破坏和粒细胞增多症的关键因素，注意力集中在粒细胞上的肾上腺素能受体和应激诱导的交感神经刺激。如果我们引入“粒细胞增多和随后的组织破坏是由交感神经刺激引起的”这一概念，那么许多生理现象的潜在机制和人类几种无法治愈的疾病的病因就可以清楚地理解。
It is well-known that physiological phenomena and certain diseases, including neonatal granulocytosis, age-associated granulocytosis, periodontitis, pancreatitis, Crohn's disease, ulcerative colitis, hemorrhoids, endometriosis, and NSADs-enteritis, are accompanied by tissue destruction and granulocytosis. We investigated what is a key factor connecting tissue destruction and granulocytosis, attention being, focused on adrenergic receptors on granulocytes and stress-induced sympathetic nerve stimulation. If we introduce the concept that "granulocytosis and subsequent tissue destruction are induced by sympathetic nerve stimulation," the mechanisms underlying many physiological phenomena and the etiology of several uncurable diseases in humans can be clearly understood.