Animal models of ulcerative colitis and their application in drug research.
Animal models of ulcerative colitis and their application in drug research.
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DOI：
10.2147/dddt.s40107
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Mizoguchi E
中科院分区：
文献类型：
--
作者：
Low D;Nguyen DD;Mizoguchi E
炎症性肠病的具体发病机制是复杂的，并且更难以解释其两个主要亚型克罗恩病和溃疡性结肠炎（UC）之间的相似性和差异性的病理生理学。动物模型是不可或缺的窥探机制的细节，这将有助于更好的临床前药物/治疗设计，以靶向参与疾病发病机制的特定成分。本文综述了对UC及其治疗策略研究特别有用的常见动物模型。最新的化合物，治疗策略，并在UC动物模型上测试的方法的最新报告也进行了讨论。
The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even more difficult to decipher the pathophysiology to explain for the similarities and differences between two of its major subtypes, Crohn’s disease and ulcerative colitis (UC). Animal models are indispensable to pry into mechanistic details that will facilitate better preclinical drug/therapy design to target specific components involved in the disease pathogenesis. This review focuses on common animal models that are particularly useful for the study of UC and its therapeutic strategy. Recent reports of the latest compounds, therapeutic strategies, and approaches tested on UC animal models are also discussed.