Predominant presence of Streptococcus anginosus in the saliva of alcoholics
Predominant presence of Streptococcus anginosus in the saliva of alcoholics
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DOI：
10.1111/j.1399-302x.2005.00242.x
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发表时间：
2005-12-01
影响因子：
--
通讯作者：
Sasaki, H
中科院分区：
文献类型：
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作者：
Morita, E;Narikiyo, M;Sasaki, H
众所周知，长期饮酒是上呼吸消化道癌症的主要危险因素。据报道，酗酒者的食管癌发病率（4.4%）远高于日本整体人口（0.0001%）。这表明慢性饮酒相关致癌作用中存在特定因素。最近，有数据显示咽峡炎链球菌与上呼吸消化道癌变之间存在显著相关性。在本研究中，S.对38例酒精中毒患者唾液中咽峡炎链球菌与口腔细菌的关系进行了研究，以确定酒精中毒患者与咽峡炎链球菌之间是否存在联系。咽峡炎感染S.对22例健康人、41例食管癌患者、32例胃炎患者和24例牙周炎患者唾液中的咽峡炎进行了检测，并与酒精中毒患者进行了比较。食管癌患者唾液中S.心绞痛患者与健康人无显著差异。S.牙周炎和胃炎患者的心绞痛症状也相似。然而，在酗酒者中，S水平极高。提示他们比健康人和一般食管癌患者更易感染S.咽峡炎感染
Chronic alcohol consumption is known to be a major risk factor for cancers of the upper aerodigestive tract. The incidence of esophageal cancer (4.4%) in alcoholics is reported to be much higher than that in the Japanese population as a whole (0.0001%). This suggests the presence of specific factors in chronic alcohol consumption-related carcinogenesis. Recently, data showing a significant correlation between Streptococcus anginosus and carcinogenesis in the upper aerodigestive tract have been reported. In this study, the ratio of S. anginosus to oral bacteria in the saliva of 38 alcoholic patients was investigated to determine if there is an association between alcoholic patients and S. anginosus infection. The level of S. anginosus in the saliva from 22 healthy people, 41 esophageal cancer patients, 32 gastritis patients, and 24 periodontitis patients was also investigated and compared to the level in alcoholic patients. In the saliva from esophageal cancer patients, the level of S. anginosus was not significantly different from that of healthy people. The levels of S. anginosus in periodontitis and gastritis patients were also similar. In alcoholics, however, there was an extremely high level of S. anginosus, suggesting that they, rather than healthy people and general esophageal cancer patients, have a high risk for S. anginosus infection.