Cerebellar Transcranial Direct Current Stimulation Effects on Saccade Adaptation
Cerebellar Transcranial Direct Current Stimulation Effects on Saccade Adaptation
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DOI：
10.1155/2015/968970
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Frens, Maarten A.
中科院分区：
文献类型：
--
作者：
Avila, Eric;van der Geest, Jos N.;Frens, Maarten A.
眼跳适应是一种小脑调节的运动学习类型，其中眼球运动系统暴露在重复错误中。不同类型的眼跳适应被认为涉及不同的潜在小脑机制。经颅直流电刺激(TDC)以一种特定于极性的方式诱导神经元兴奋性的变化，并为不同大脑区域的学习提供了一种调制的、非侵入性的功能洞察。我们的目标是在使用tDCs的适应过程中调节小脑对眼跳增加的影响。受试者在接受由小接触电极输送的1.5 mA正极小脑TDC的同时，进行了向内(n=10)或向外(n=10)的扫视适应实验(25%的扫视靶步)。与假刺激相比，tDCs增加了向内跳动适应的学习，但不影响向外适应的学习。这可能意味着内向适应和外适应在小脑中的可塑性机制是不同的。TDCs可能影响了特定的小脑区域，这些区域有助于向内适应，而不是向外适应。我们得出结论，tDCs可以作为一种神经调节技术来改变小脑的眼动输出，可以说是通过参与更广泛的小脑区域和增加可用的学习资源。
Saccade adaptation is a cerebellar-mediated type of motor learning in which the oculomotor system is exposed to repetitive errors. Different types of saccade adaptations are thought to involve distinct underlying cerebellar mechanisms. Transcranial direct current stimulation (tDCS) induces changes in neuronal excitability in a polarity-specific manner and offers a modulatory, noninvasive, functional insight into the learning aspects of different brain regions. We aimed to modulate the cerebellar influence on saccade gains during adaptation using tDCS. Subjects performed an inward (n = 10) or outward (n = 10) saccade adaptation experiment (25% intrasaccadic target step) while receiving 1.5 mA of anodal cerebellar tDCS delivered by a small contact electrode. Compared to sham stimulation, tDCS increased learning of saccadic inward adaptation but did not affect learning of outward adaptation. This may imply that plasticity mechanisms in the cerebellum are different between inward and outward adaptation. TDCS could have influenced specific cerebellar areas that contribute to inward but not outward adaptation. We conclude that tDCS can be used as a neuromodulatory technique to alter cerebellar oculomotor output, arguably by engaging wider cerebellar areas and increasing the available resources for learning.