Spatio-temporal variations in cell-free layer formation near bifurcations of small arterioles
Spatio-temporal variations in cell-free layer formation near bifurcations of small arterioles
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DOI：
10.1016/j.mvr.2011.11.003
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发表时间：
2012-03-01
影响因子：
3.1
通讯作者：
Kim, Sangho
中科院分区：
文献类型：
--
作者：
Ong, Peng Kai;Jain, Swati;Kim, Sangho
小动脉分叉处的血流分配可能导致分叉处上游和下游血管中无细胞层形成的时空变化。为了研究这种效应，我们定量分析了正常生理流动条件下大鼠提睾肌小动脉分叉附近无细胞层的特征。为了模拟与人类的血液流变学相关性，通过输注右旋糖酐500将红细胞聚集升高至正常状态下在人类中观察到的水平。在母体和较大的子体血管中观察到层宽度的空间变化。在邻近侧分支的载瘤血管壁中通常观察到比其对侧壁更明显的层宽衰减。在较大子血管的对侧始终发现比相邻壁更厚的层宽度。因此，在较大的子血管的相对侧上可以形成层宽度的大的不对称性，其显著更大（P
Blood flow partitioning at an arteriolar bifurcation could lead to spatio-temporal variations in cell-free layer formation in The upstream and downstream vessels of the bifurcation. To investigate this effect, we quantitatively analyzed characteristics of the cell-free layer in the vicinity of an arteriolar bifurcation in the rat cremaster muscle in normal physiological flow conditions. To simulate hemorheological relevance to humans, red blood cell aggregation was elevated by infusion of Dextran 500 to levels seen in humans in normal states. Spatial variations of the layer width were observed in both the parent and larger daughter vessels. A more pronounced attenuation of the layer width was generally observed in the parent vessel at its wall adjacent to the side branch than at its opposite wall. A thicker layer width was consistently found at the opposite than adjacent wall of the larger daughter vessel. Accordingly, large asymmetries of the layer widths could be developed on opposite sides of the larger daughter vessel, which were significantly greater (P