The incidence of neutralizing antibodies for swine influenza virus in the sera of human beings of different ages
The incidence of neutralizing antibodies for swine influenza virus in the sera of human beings of different ages
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DOI：
10.1084/jem.63.5.669
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发表时间：
1936-05-01
影响因子：
15.3
通讯作者：
Shope, RE
中科院分区：
文献类型：
--
作者：
Shope, RE
对123名个体的血清进行了保护小鼠免受猪流感病毒感染的能力测试，并根据年龄组和既往流感发作史对结果进行了分类。这些血清和人流感病毒的保护试验结果以前曾有报道，本报告比较了这两种病毒的结果。12名3天至1个月大的婴儿的血清始终中和猪流感病毒。7名2至9个月大的婴儿的血清未能显示出对这种病毒的保护作用。1 ~ 5岁儿童14份血清中的1份; 8名6-9岁儿童中的2名和7名10-12岁儿童中的4名完全或几乎完全中和了病毒。除少数例外情况外，21岁以上的人提供了完全保护; 45名有流感阳性史的人中有44人拥有中和血清; 29名无流感发作史的人中有25人也中和了猪流感病毒。历史的准确性受到作者的质疑。在人类血清中发现能够中和猪流感病毒的抗体的意义进行了讨论，与1918年流行的病毒类型有关。
Sera from 123 individuals were tested for their capacity to protect mice against swine influenza virus and the results classified according to age groups and previous history of an attack of influenza. Results of protection tests with these sera and human influenza virus had been previously reported, and results with the two viruses are compared in this report. The sera of 12 infants from 3 days to 1 month of age consistently neutralized swine influenza virus. Sera of 7 babies from 2 to 9 months of age failed to show protection against this virus. One of 14 sera from children between the ages of 1 and 5 yrs.; 2 of 8 from children 6-9 yrs. and 4 of 7 from children 10-12 yrs. neutralized the virus completely or almost completely. Those from persons from 21 yrs. on, with few exceptions, afforded complete protection; 44 of 45 persons giving a positive history of influenza possessed neutralizing serum; 25 of 29 persons with no history of an attack of influenza also neutralized swine influenza virus. The accuracy of the histories is questioned by the authors. The significance of the finding in human sera of antibodies capable of neutralizing swine influenza virus is discussed in relation to the type of virus present in the 1918 epidemic.