Chemically modified bovine beta-lactoglobulin inhibits human papillomavirus infection
Chemically modified bovine beta-lactoglobulin inhibits human papillomavirus infection
复制标题
化学修饰的牛β-乳球蛋白抑制人乳头瘤病毒感染
DOI：
10.1016/j.micinf.2013.03.003
复制
发表时间：
2013-06-01
影响因子：
5.8
通讯作者：
Jiang, Shibo
中科院分区：
文献类型：
--
作者：
Lu, Lu;Yang, Xia;Jiang, Shibo
Previous studies have shown that 3-hydroxyphthalic anhydride-modified bovine beta-lactoglobulin is a promising anti-HIV microbicide candidate. Here we found that this chemically modified protein, designated JB01, exhibited highly potent antiviral activity against infection by human papillomaviruses (HPV), including HPV6, HPV16 and HPV18. Its anti-HPV activity was correlated with the percentage of modified lysine and arginine residues in JB01. This modified milk protein had no cytotoxicity at the concentration of 1 mg/ml, and it is highly stable at room temperature and 37 degrees C for at least 12 weeks. These results suggest that JB01 has good potential to be developed as an effective, safe and inexpensive antiviral agent for treatment and prevention of HPV infection. (c) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
