Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
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DOI：
10.1101/2020.11.27.401042
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发表时间：
2020-11
期刊：
影响因子：
8.8
通讯作者：
C. Soares-Cunha;R. Correia;A. V. Domingues;B. Coimbra;Nivaldo A. P. de Vasconcelos;L. Pinto;N. Sousa;A. Rodrigues
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作者：
C. Soares-Cunha;R. Correia;A. V. Domingues;B. Coimbra;Nivaldo A. P. de Vasconcelos;L. Pinto;N. Sousa;A. Rodrigues
伏隔核（NAc）是动机行为的关键区域。NAc中棘神经元分为表达多巴胺受体D1和D2的神经元。传统上，D1-和d2 - msn被描述为在强化中具有相反的作用，但最近的证据表明d2 - msn的作用更为复杂。本研究表明，在动机行为的不同阶段，光遗传学对D2-MSN对腹侧苍白球（VP）投射的调节对动机有不同的影响。在奖励预测提示时激活D2-MSN-VP投射导致动机驱动增加，而在奖励传递时激活导致动机降低；光抑制具有相反的行为效果。此外，在自由选择的工具任务中，动物更喜欢产生一个颗粒的杠杆，而不是颗粒加D2-MSN-VP的光遗传激活，反之亦然。综上所述，D2-MSN-VP预测在动机行为的不同阶段发挥不同（甚至相反）的作用。
The nucleus accumbens (NAc) is a key region in motivated behaviors. NAc medium spiny neurons (MSNs) are divided into those expressing dopamine receptor D1 or D2. Classically, D1- and D2-MSNs have been described as having opposing roles in reinforcement but recent evidence suggests a more complex role for D2-MSNs. Here we show that optogenetic modulation of D2-MSN to ventral pallidum (VP) projections during different stages of motivated behavior has contrasting effects in motivation. Activation of D2-MSN-VP projections during a reward-predicting cue results in increased motivational drive, whereas activation at reward delivery results in decreased motivation; optical inhibition has the opposite behavioral effect. In addition, in a free choice instrumental task, animals prefer the lever that originates one pellet in opposition to pellet plus D2-MSN-VP optogenetic activation, and vice versa for optogenetic inhibition. In summary, D2-MSN-VP projections play different (and even opposing) roles in distinct phases of motivated behavior.