Inorganic arsenic in Chinese food and its cancer risk
Inorganic arsenic in Chinese food and its cancer risk
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DOI：
10.1016/j.envint.2011.05.007
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发表时间：
2011-10-01
影响因子：
11.8
通讯作者：
Zhu, Yong-Guan
中科院分区：
文献类型：
--
作者：
Li, Gang;Sun, Guo-Xin;Zhu, Yong-Guan
即使是中等程度的砷暴露也可能导致健康问题，因此定量测定中国不同人群食物中无机砷（iAs）的暴露量是必要的。通过分析中国国民营养与健康调查（CNNHS）的数据和收集主要食物组中iAs的报告值，我们开发了一个计算中国不同地区平均iAs日摄入量的框架。在此基础上，确定性和概率量化的癌症风险从食品中的砷。本文介绍了由于摄入砷污染的食品的健康风险的估计。获得了每个人和总人口的估计数。总人群的iAs日摄入量约为42 μ g/天（-1），大米是iAs总摄入量的最大贡献者，约占60%。对于成年人来说，从食物iAs摄入中增加的终生癌症风险为每10万人106人，人口癌症风险中位数为每10万人177人，各地区之间存在差异。南方地区人群患癌风险高于北方地区和总人群。敏感性分析表明，癌症斜率因子、大米摄入率、水产品摄入率和大米中iAs浓度是模型中最相关的变量，它们对终身癌症风险增量的方差贡献较大。我们的结论是，大米可能是最大的贡献者的iAs通过食物的路线，为中国人民。来自南方的人口比来自北方的人口和整个人口有更大的癌症风险。(C)2011爱思唯尔有限公司版权所有。
Even moderate arsenic exposure may lead to health problems, and thus quantifying inorganic arsenic (iAs) exposure from food for different population groups in China is essential. By analyzing the data from the China National Nutrition and Health Survey (CNNHS) and collecting reported values of iAs in major food groups, we developed a framework of calculating average iAs daily intake for different regions of China. Based on this framework, cancer risks from As in food was deterministically and probabilistically quantified. The article presents estimates for health risk due to the ingestion of food products contaminated with arsenic. Both per individual and for total population estimates were obtained. For the total population, daily iAs intake is around 42 mu g day(-1), and rice is the largest contributor of total iAs intake accounting for about 60%. Incremental lifetime cancer risk from food iAs intake is 106 per 100,000 for adult individuals and the median population cancer risk is 177 per 100,000 varying between regions. Population in the Southern region has a higher cancer risk than that in the Northern region and the total population. Sensitive analysis indicated that cancer slope factor, ingestion rates of rice, aquatic products and iAs concentration in rice were the most relevant variables in the model, as indicated by their higher contribution to variance of the incremental lifetime cancer risk. We conclude that rice may be the largest contributor of iAs through food route for the Chinese people. The population from the South has greater cancer risk than that from the North and the whole population. (C) 2011 Elsevier Ltd. All rights reserved.