Cerebral palsy is characterized by protein mediators in cord serum
Cerebral palsy is characterized by protein mediators in cord serum
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DOI：
10.1002/ana.10809
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发表时间：
2004-02-01
影响因子：
11.2
通讯作者：
Hallman, M
中科院分区：
文献类型：
--
作者：
Kaukola, T;Satyaraj, E;Hallman, M
脑性瘫痪（CP）是儿童时期的一种主要神经发育障碍。宫内感染和CP之间的关联已被报道。我们研究了足月儿和早产儿脐带血中炎症介质与CP的关系。对19例CP儿童和19例妊娠匹配的配对对照进行了区域性多中心研究。CP儿童（n=27）与出生时妊娠相似的对照组（n=25）进行了进一步比较。分析了78种蛋白质介质的血清水平。11种分析物与病例和对照组的妊娠时间相关。配对分析显示，CP患儿B淋巴细胞趋化因子、睫状神经营养因子、表皮生长因子、白细胞介素（IL）-5、IL-12、IL-13、IL-15、巨噬细胞移动抑制因子、单核细胞趋化蛋白-3、γ干扰素诱导的单核细胞因子、肿瘤坏死因子相关凋亡诱导配体均高于对照组（P <0.05）。早产儿CP表现出较高的表皮生长因子和较低水平的粒细胞-巨噬细胞集落刺激因子，IL-2，巨噬细胞衍生的趋化因子，肺和活化调节趋化因子比他们的配对对照。炎症介质和生长因子作为胎儿对出生后表现为永久性脑损伤的损伤的反应的足迹。早产儿和足月儿在出生时的细胞因子模式不同。
Cerebral palsy (CP) is a major neurodevelopmental disability in childhood. An association between intrauterine infection and CP has been reported. We examined the relationship between inflammatory mediators in cord serum and CP in term and preterm children. Regional multicenter study was conducted on 19 CP children and 19 gestation-matched paired controls. CP children (n=27) were further compared with controls of similar gestation at birth (n=25). Serum levels of 78 protein mediators were analyzed. Eleven analytes correlated with the length of gestation both in cases and controls. In paired analysis, B-lymphocyte chemoattractant, ciliary neurotrophic factor, epidermal growth factor, interleukin (IL)-5, IL-12, IL-13, IL-15, macrophage migration inhibitory factor, monocyte chemoattractant protein-3, monokine induced by interferon gamma, and tumor necrosis factor-related apoptosis-inducing ligand were higher in children with CP (Pless than or equal to0.05). Preterm infants with CP showed higher epidermal growth factor and lower levels of granulocyte-macrophage colony-stimulating factor, IL-2, macrophage-derived chemokine, and pulmonary and activation-regulated chemokine than their paired controls. Inflammatory mediators and growth factors serve as a footprint of the fetal response to an insult manifesting after birth as a permanent brain damage. The cytokine patterns at birth differ between premature and term infants who develop CP.