Tissue factor levels in type 2 diabetes mellitus
Tissue factor levels in type 2 diabetes mellitus
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DOI：
10.1007/s00011-017-1030-x
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发表时间：
2017-05-01
影响因子：
6.7
通讯作者：
Pretorius, Etheresia
中科院分区：
文献类型：
--
作者：
Soma, Prashilla;Swanepoel, Albe C.;Pretorius, Etheresia
前言2型糖尿病是一种与止血障碍相关的流行病，可促进糖尿病血管疾病的发展和加速动脉粥样硬化。在这一人群中，高凝状态以及红细胞的病理变化很普遍。这主要是由于上调循环inflammatory markers.Materials和方法在这里，我们看了组织因子（TF）水平使用ELISA，在糖尿病患者的样本中，有和没有心血管并发症。从南非比勒陀利亚的Steve Biko学术医院的糖尿病诊所招募糖尿病受试者。20例糖尿病合并心血管疾病和22例无心血管疾病的患者参加了研究。结果和结论与对照组相比，糖尿病组的TF水平显着升高。我们建议，病理性血浆TF活性，作为血栓病理学倾向增加的标志物，应进行研究。可能降低TF水平的药物也可能降低血栓性并发症。
Introduction Type 2 diabetes mellitus is a pandemic associated with disturbance in haemostasis that could contribute to the development of diabetic vascular disease and accelerated atherosclerosis. In this population, hypercoagulation is prevalent, as well as pathological changes to erythrocytes. This is mainly due to upregulated circulating inflammatory markers.Materials and methods Here we looked at tissue factor (TF) levels using ELISA, in a sample of diabetics, with and without cardiovascular complications. Diabetic subjects were recruited from the diabetic clinic at Steve Biko Academic Hospital, Pretoria, South Africa. 20 diabetics with cardiovascular disease and 22 without were enrolled to participate.Results and conclusion TF levels were significantly elevated in both diabetic groups when compared to the controls. We suggest that pathologic plasma TF activity, as marker of increased propensity of clot pathology, should be investigated. Agents that might lower TF levels might also possibly lower thrombotic complications.