Fabrication of 3D aligned nanofibrous tubes by direct electrospinning
Fabrication of 3D aligned nanofibrous tubes by direct electrospinning
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DOI：
10.1039/c3tb20197j
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发表时间：
2013-01-01
影响因子：
7
通讯作者：
Zhang, Miqin
中科院分区：
文献类型：
--
作者：
Jana, Soumen;Zhang, Miqin
静电纺丝已成为生产纳米纤维的主流技术。尽管其受欢迎，但通过静电纺丝以管状形式生产对齐的纳米纤维结构仍然是一个挑战。在这里，我们提出了一个简单的静电纺丝方法，可以产生纳米纤维管与随机取向或对齐的纳米纤维。我们研究了力量和关键的实验因素，支配生产的纳米纤维结构的形成和结构特性。我们成功地展示了使用一种天然聚合物和两种合成聚合物（壳聚糖、聚己内酯和聚乙烯基吡咯烷酮）生产这些管状结构。这些聚合物已经证明了它们在医学和各种工程领域的广泛应用。我们在模型生物应用中进一步证明，在对齐的纳米纤维管状支架的内表面上培养的肌细胞能够形成如天然肌肉组织中那样组织的对齐且密集的肌管。
Electrospinning has become a mainstream technology for production of nanofibers. Despite its popularity, production of aligned nanofibrous constructs in a tubular form by electrospinning remains a challenge. Here, we present a simple electrospinning approach that can produce nanofibrous tubes with either randomly oriented or aligned nanofibers. We examined the forces and key experimental factors that govern the formation and structural properties of produced nanofibrous constructs. We successfully demonstrated the production of these tubular constructs with one natural and two synthetic polymers (chitosan, polycaprolactone and poly(vinyl pyrrolidone)). These polymers have demonstrated their broad applicability in medicine and various engineering fields. We further demonstrated in a model bio-application that muscle cells cultured on the inner surface of an aligned nanofibrous tubular scaffold enabled the formation of aligned and densely populated myotubes organized as in native muscle tissues.