Spatial regulation of epidermal growth factor receptor signaling by endocytosis.
Spatial regulation of epidermal growth factor receptor signaling by endocytosis.
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DOI：
10.3390/ijms14010072
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发表时间：
2012-12-20
影响因子：
5.6
通讯作者：
Ceresa BP
中科院分区：
文献类型：
--
作者：
Ceresa BP
细胞表面受体的信号传导似乎是相对直接的：配体结合到受体的细胞外区域，生化变化被传递到细胞内。然而，由于调节信号的各种机制，这个过程比最初看起来要复杂得多。为了有效地靶向这些受体的药理作用，需要更全面地了解它们的信号是如何调节的。本文以表皮生长因子受体（EGFR）为模型，讨论了内吞通路如何调节受体信号。特别是，信号的空间调节被检查。讨论的领域包括：内吞运输如何影响生物学/病理学，研究受体内吞作用和信号传导之间关系的不同方法，内吞途径如何控制EGFR的发展：效应通讯和EGFR介导的细胞生物学。
Signaling by cell surface receptors appears to be relatively straight-forward: ligand binds to the extracellular domain of the receptor and biochemical changes are communicated into the cell. However, this process is more complex than it first seems due to the various mechanisms that regulate signaling. In order to effectively target these receptors for pharmacological purposes, a more complete understanding of how their signaling is regulated is needed. Here, how the endocytic pathway regulates receptor signaling is discussed, using the epidermal growth factor receptor (EGFR) as a model. In particular, the spatial regulation of signaling is examined. Areas of discussion include: how endocytic trafficking affects biology/pathology, varying approaches for studying the relationship between receptor endocytosis and signaling, and developments in how the endocytic pathway controls EGFR:effector communication and EGFR-mediated cell biology.
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影响因子：
6.6
作者：
Barbieri, MA;Fernandez-Pol, S;Stahl, PD
通讯作者：
Stahl, PD
DOI：
10.1111/j.1600-0854.2011.01305.x
发表时间：
2012-02
期刊：
Traffic (Copenhagen, Denmark)
影响因子：
--
作者：
Eden ER;Huang F;Sorkin A;Futter CE
通讯作者：
Futter CE
突变动力蛋白的诱导特异性阻断内吞涂层囊泡的形成。
影响因子：
7.8
作者：
Damke, H;Baba, T;Warnock, D E;Schmid, S L
通讯作者：
Schmid, S L
影响因子：
7.8
作者：
FELDER, S;LAVIN, J;SCHLESSINGER, J
通讯作者：
SCHLESSINGER, J
影响因子：
4.8
作者：
Dai, PG;Xiong, WC;Mei, L
通讯作者：
Mei, L