Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies.
Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies.
复制标题
精神分裂症患者的犬尿氨酸和色氨酸水平以及抗麦胶蛋白免疫球蛋白 G 抗体升高。
DOI：
10.1097/psy.0000000000000352
复制
发表时间：
2016
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
Okusaga,Olaoluwa;Fuchs,Dietmar;Reeves,Gloria;Giegling,Ina;Hartmann,AnnetteM;Konte,Bettina;Friedl,Marion;Groer,Maureen;Cook,ThomasB;Stearns-Yoder,KellyA;Pandey,JanardanP;Kelly,DeannaL;Hoisington,AndrewJ;Lowry,ChristopherA;
目的已有多项研究报道了非乳酸面筋敏感性与精神分裂症之间的关系。免疫和犬尿氨酸(KYN)途径也参与了精神分裂症的病理生理过程，某些促炎免疫介质可增加KYN和降低色氨酸(Trp)水平。方法检测950例精神分裂症患者血清中抗胶质蛋白免疫球蛋白G(IgG)、KYN和Trp水平。抗体水平在对照受试者的第90个百分位数或更高的患者(占所有患者的21.9%)被归类为抗醇溶蛋白抗体升高。采用独立t检验和线性回归模型比较抗醇溶蛋白抗体升高患者和无升高患者的Trp、Kyn和Kyn-Trp比率(Trp代谢指标)。结果抗胶质蛋白Ig G升高患者的KYN和KYN-Trp比值较高(几何均数[标准差{SD}]=2.6 5[0.2 5]µm ol/L比2.2 5[0.2 3]µm o l/L[p<；001]和0.05[0.26]对0.04[0.25；p=.001])，研究结果对潜在的人口学和临床混杂因素进行了强有力的调整。抗醇溶蛋白Ig G与KYN、KYN-Trp比值呈正相关(r=0.12，p<；001；r=0.11，p=。002)。Trp在两组间无差异，且与抗胶质蛋白Ig无关。结论我们的研究结果将精神病患者的非乳糜性面筋敏感性与Trp代谢的KYN途径联系起来，并提示潜在的个体化治疗靶点。
ObjectiveSeveral studies have reported an association between nonceliac gluten sensitivity and schizophrenia. Immune and kynurenine (KYN) pathways have also been implicated in the pathophysiology of schizophrenia, and certain proinflammatory immune mediators may increase KYN and reduce tryptophan (TRP) levels.MethodsWe measured serum antigliadin immunoglobulin G (IgG), KYN, and TRP in 950 patients with schizophrenia. Patients with antibody level at the 90th percentile or higher of control participants (21.9% of all patients) were classified as having elevated antigliadin IgG. Independent t tests and linear regression models were used to compare TRP, KYN, and KYN-TRP ratio (indicator of TRP metabolism) between patients with and those without elevated antigliadin IgG. The correlation between antigliadin IgG and TRP, KYN, and the ratio was also evaluated in the patients.ResultsKYN and KYN-TRP ratio were higher in patients with elevated antigliadin IgG (geometric mean [standard deviation {SD}]= 2.65 [0.25] µmol/L versus 2.25 [0.23] µmol/L [p<. 001] and 0.05 [0.26] versus 0.04 [0.25; p=. 001] respectively), findings robust to adjustment for potential demographic and clinical confounders. Antigliadin IgG positively correlated with KYN and KYN-TRP ratio (r= 0.12, p<. 001; r= 0.11, p=. 002). TRP did not differ between the two groups and did not correlate with antigliadin IgG.ConclusionsOur results connect nonceliac gluten sensitivity with the KYN pathway of TRP metabolism in psychotic illness and hint toward potential individualized treatment targets.