Prognostic significance of stromal versican expression in human endometrial cancer
Prognostic significance of stromal versican expression in human endometrial cancer
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DOI：
10.1093/annonc/mdl370
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发表时间：
2007-02-01
影响因子：
50.5
通讯作者：
Hiramatsu, Y.
中科院分区：
文献类型：
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作者：
Kodama, J.;Hasengaowa;Hiramatsu, Y.
背景：Versican表达可能促进肿瘤的侵袭和转移。然而，多功能蛋白聚糖在人子宫内膜癌中的表达很少被表征。本研究的目的是探讨多功能蛋白聚糖在子宫内膜癌中的表达。患者和方法：我们采用化学方法研究了167例子宫内膜癌中多功能蛋白聚糖的表达，并分析了其与各种临床病理特征的相关性，包括患者的预后。间质多功能蛋白聚糖的表达在晚期乳腺癌中显著增高，高级别（P = 0.049）、淋巴结转移（P = 0.012）和卵巢转移（P = 0.024）。多功能蛋白聚糖在有淋巴结转移（P = 0.014）和淋巴管间隙受累（P = 0.014）的患者中的表达显著增高。间质多功能蛋白聚糖高表达患者的无病生存率（DFS）和总生存率（OS）显著低于间质多功能蛋白聚糖低表达患者（P < 0.0001）。多因素分析显示，间质多功能蛋白聚糖的高表达是DFS和OS的独立预后因素。结论：间质多功能蛋白聚糖的富集可能与子宫内膜癌的肿瘤进展有关。间质多功能蛋白聚糖表达可作为子宫内膜癌患者预后不良的指标。
Background: Versican expression may enhance tumor invasion and metastasis. However, the expression of versican in human endometrial cancer has seldom been characterized. The aim of this study was to investigate versican expression in endometrial cancers.Patients and methods: We immunohistochemically investigated the expression of versican protein in 167 endometrial cancers and analyzed the correlation with various observed clinicopathological features, including patient outcome.Results: Stromal versican expression was significantly higher in the advanced-stage (P = 0.010) and high-grade (P = 0.049) cancers, lymph node metastasis (P = 0.012), and ovarian metastasis (P = 0.024). Epithelial versican expression was significantly higher in patients with lymph node metastasis (P = 0.014) and lymph-vascular space involvement (P = 0.014). The disease-free survival (DFS) and overall survival (OS) rates of patients exhibiting high stromal versican expression were significantly lower than those of patients exhibiting low stromal versican expression (P < 0.0001). Multivariate analysis showed that high stromal versican expression was an independent prognostic factor for DFS and OS.Conclusions: Versican enrichment of the stroma may be associated with tumor progression in endometrial cancer. Stromal versican expression can serve as an indicator of poor prognosis for patients with endometrial cancer.