VARIATION IN SUSCEPTIBILITY TO ATHEROSCLEROSIS AMONG INBRED STRAINS OF MICE
VARIATION IN SUSCEPTIBILITY TO ATHEROSCLEROSIS AMONG INBRED STRAINS OF MICE
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DOI：
10.1016/0021-9150(85)90138-8
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发表时间：
1985-01-01
期刊：
影响因子：
5.3
通讯作者：
HOLMES, P
中科院分区：
文献类型：
--
作者：
PAIGEN, B;MORROW, A;HOLMES, P
给10只近交系小鼠喂食含有1.25%胆固醇、0.5%胆酸和15%脂肪的致动脉粥样硬化饮食。检查菌株的血浆胆固醇和甘油三酯水平以及主动脉壁中含脂质病变的形成。在致动脉粥样硬化饮食14周后，各品系的病变形成频率差异很大，范围为0-1.8个病变/小鼠。最易形成病变的是BALB/cJ、C3 H/J、A/J、SWR/J、NZB/J、< 129/J、AKR/J、DBA/2 J、<C57 L/J <C57 BL/6 J。饮食5周后，血浆总胆固醇从131毫克/分升到328毫克/分升不等的菌株，但是，总胆固醇水平和病变形成的敏感性之间几乎没有相关性（r = 0.29）。饮食5周后，血浆甘油三酯的变化小于胆固醇，范围为137-220 mg/dl。分析近交系小鼠之间的遗传差异可能为脂质代谢和动脉粥样硬化的发展提供有用的见解。
Ten inbred stains of mice were fed an atherogenic diet containing 1.25% cholesterol, 0.5% cholic acid and 15% fat. The strains were examined for plasma cholesterol and triglyceride levels and for formation of lipid-containing lesions in the aortic wall. The strains differed considerably in the frequency of lesion formation after 14 weeks on the atherogenic diet with a range of 0-1.8 lesions/mouse. The most susceptible to lesion formation from the least susceptible to the most susceptible was BALB/cJ, C3H/J, A/J, SWR/J, NZB/J, < 129/J, AKR/J, DBA/2J, < C57L/J < C57BL/6J. Total plasma cholesterol after 5 weeks on the diet varied from 131 mg/dl to 328 mg/dl among strains; however, there was little correlation between total cholesterol levels and susceptibility to lesion formation (r = 0.29). Plasma triglycerides after 5 weeks on the diet varied less than cholesterol with a range of 137-220 mg/dl. An analysis of the genetic differences among inbred strains of mice might provide useful insights into lipid metabolism and the development of atherosclerosis.