Quellenin, a new anti-Saprolegnia compound isolated from the deep-sea fungus, Aspergillus sp. YK-76
Quellenin, a new anti-Saprolegnia compound isolated from the deep-sea fungus, Aspergillus sp. YK-76
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DOI：
10.1038/s41429-018-0053-z
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发表时间：
2018-04
期刊：
影响因子：
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通讯作者：
Konami Takahashi;Kazunari Sakai;Wataru Fukasawa;Y. Nagano;S. O. Sakaguchi;A. O. Lima;V. Pellizari
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文献类型：
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作者：
Konami Takahashi;Kazunari Sakai;Wataru Fukasawa;Y. Nagano;S. O. Sakaguchi;A. O. Lima;V. Pellizari
寄生水霉（Saprolegnia parasitica）属于卵菌纲，是鲑鱼、鳟鱼等鱼类的重要致病菌，给水产养殖业造成了巨大的危害和损失。以前，孔雀石绿色是一种有效的药物，用于控制水霉病。然而，由于其致突变性，这种药物已在世界各地被禁止。因此，迫切需要新的抗水霉病化合物。作为发现生物活性化合物的一个新前沿，我们重点从深海真菌中分离抗水霉病化合物。本文从91个深海真菌菌株的546个培养液中筛选出一个新化合物，命名为quellenin（1），以及三个已知化合物diorcinol（2），violaceol-I（3）和violaceol-II（4）。YK-76该菌株是从一个Osedaxsp.环节动物，通常称为食骨虫，在巴西附近的圣保罗岭采集。化合物2、3、4具有抗S.寄生活性我们的研究结果表明，diorcinol和violaceol类似物，并可能是很好的领导候选人的发展，新的代理，以防止水霉病。
Saprolegnia parasitica, belonging to oomycetes, is one of virulent pathogen of fishes such as salmon and trout, and causes tremendous damage and losses in commercial aquacultures by saprolegniasis. Previously, malachite green, an effective medicine, had been used to control saprolegniasis. However, this drug has been banned around the world due to its mutagenicity. Therefore, novel anti-saprolegniasis compounds are urgently needed. As a new frontier to discover bioactive compounds, we focused on the deep-sea fungi for the isolation of anti-saprolegniasis compounds. In this paper, on the course of anti-saprolegniasis agents from 546 cultured broths of 91 deep-sea fungal strains, we report a new compound, named quellenin (1) together with three known compounds, diorcinol (2), violaceol-I (3) and violaceol-II (4), from deep-sea fungusAspergillussp. YK-76. This strain was isolated from anOsedaxsp. annelid, commonly called bone-eating worm, collected at the São Paulo Ridge in off Brazil. Compounds 2, 3 and 4 showed anti-S. parasiticaactivity. Our results suggest that diorcinol and violaceol analogs and could be good lead candidates for the development of novel agents to prevent saprolegniasis.