Investigation of the self-association of an amphiphilic drug in aqueous solution
Investigation of the self-association of an amphiphilic drug in aqueous solution
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两亲性药物在水溶液中自缔合的研究
DOI：
10.1039/f19807600570
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
S. Agarwal
中科院分区：
文献类型：
--
作者：
D. Attwood;S. Agarwal
使用光散射技术研究了抗高血压药物曲美芬在水和电解质水溶液中的缔合模式。光散射曲线没有表现出显着的不连续性，可归因于一个临界胶束浓度，不能使用胶束缔合的质量作用模型进行模拟。几个逐步关联的一个和两个参数模型的适用性进行了研究。该协会是最令人满意的描述使用一个双参数模型，其中二聚化的平衡常数被认为是一个独立的变量和更高的逐步关联常数是相同的。该模型的关联成功地预测了数均关联度的蒸汽压渗透测定系统。在空气/溶液界面的表面活性的浓度依赖性也是一致的逐步协会。
The pattern of association of the antihypertensive drug, trimetaphan camphorsulphonate, in water and aqueous electrolyte solution has been examined using light scattering techniques. Light scattering curves exhibited no significant discontinuity attributable to a critical micelle concentration and could not be simulated using the mass action model for micellar association. The applicability of several one- and two-parameter models of stepwise association has been examined. The association was most satisfactorily described using a two-parameter model in which the equilibrium constant for dimerization was considered as an independent variable and higher stepwise association constants were identical. This model of association successfully predicted the number-average degree of association of the system as determined by vapour pressure osmometry. The concentration dependence of the surface activity at the air/solution interface was also consistent with stepwise association.