IgG subclasses in the serum and sputum from patients with bronchiectasis
IgG subclasses in the serum and sputum from patients with bronchiectasis
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DOI：
10.1136/thx.53.6.463
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发表时间：
1998-06-01
期刊：
影响因子：
10
通讯作者：
Stockley, RA
中科院分区：
文献类型：
--
作者：
Hill, SL;Mitchell, JL;Stockley, RA
背景--IgG亚类缺陷通常与复发性肺部感染有关。支气管扩张症患者的一个大的特点组中的缺陷的患病率以前没有established.Methods-Serum IgG亚类浓度在89例支气管扩张症进行了比较，从一组82年龄和性别匹配的正常健康对照。还评估了44例患者的痰液IgG亚类浓度。白蛋白作为蛋白质从血浆渗出的标志物进行测量，以确定局部IgG亚类production.Results-The IgG（1），IgG（2）和IgG（3）的血清浓度增加的患者与对照组相比，而IgG，浓度没有。基于观察到的浓度低于对照组范围的下限，支气管扩张患者中亚类1-3缺乏的总体发生率为1%，亚类4缺乏的总体发生率为5%。痰液中IgG亚类的浓度部分取决于炎症的程度，如通过肉眼观察化脓的外观所评估的。痰液：血清亚类浓度和痰液：血清白蛋白的比例的比较，但是，发现所有的亚类都存在于更大的浓度比可以占由transsudation单独。结论-一个新的正常对照范围血清IgG亚类已经建立，从这个范围内发现，IgG亚类缺乏症在一组支气管扩张症患者的支气管扩张症是比较罕见的。在这些患者的肺中也提示了显著程度的局部IgG产生。
Background-IgG subclass deficiency is often associated with recurrent pulmonary infections. The prevalence of deficiency in a large well characterised group of patients with bronchiectasis has not previously been established.Methods-Serum IgG subclass concentrations in 89 patients with bronchiectasis were compared with those obtained from a group of 82 age and sex matched normal healthy controls. Sputum IgG subclass concentrations were also assessed in 44 of the patients. Albumin was measured as a marker of protein transudation from plasma to determine the degree of local IgG subclass production.Results-The serum concentrations of IgG(1), IgG(2) and IgG(3) were increased in the patients compared with the control group whereas IgG, concentrations were not. There was an overall incidence of deficiency of 1% for subclasses 1-3 and 5% for subclass 4 in patients with bronchiectasis based on observed concentrations being below the lower Limit of the control group range. The concentrations of IgG subclasses in sputum were partly dependent upon the degree of inflammation as assessed by the macroscopic appearance of purulence. A comparison of the ratio of sputum:serum subclass concentration and sputum:serum albumin, however, revealed that all of the subclasses were present at greater concentrations than could be accounted for by transudation alone.Conclusions-A new normal control range for serum IgG subclasses has been established and from this range it was found that IgG subclass deficiency in a group of unselected patients with bronchiectasis was comparatively rare. A significant degree of local IgG production was also suggested in the lungs of these patients.