A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel
A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel
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一种新型可注射局部疏水性药物输送系统：热敏水凝胶中的可生物降解纳米颗粒
DOI：
10.1016/j.ijpharm.2008.03.023
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发表时间：
2008-07-09
影响因子：
5.8
通讯作者：
Wei, YuQuan
中科院分区：
文献类型：
--
作者：
Gou, MaLing;Li, XingYi;Wei, YuQuan
在本文中，展示了一种新型局部疏水性药物递送系统：热敏水凝胶中的纳米颗粒。首先，以和厚朴酚为模型疏水性药物，通过乳液溶剂蒸发法制备负载聚(ε-己内酯)聚(乙二醇)-聚(ε-己内酯)(PCEC)纳米粒，然后将其掺入到热敏F127水基质中。所获得的可注射疏水性药物递送系统可以作为和厚朴酚原位缓释的储库。复合基质的下临界溶解温度（LCST）随着掺入纳米颗粒质量的增加或系统中残留有机溶剂量的减少而增加。研究了和厚朴酚的体外释放曲线，结果表明和厚朴酚可以从系统中持续释放。所描述的注射药物递送系统对于疏水性药物（例如和厚朴酚）的局部递送可能具有巨大的潜在应用。 (C) 2008 Elsevier B.V. 保留所有权利。
In this article, a novel local hydrophobic drug delivery system: nanoparticles in thermo-sensitive hydrogel, was demonstrated. First, honokiol, as a model hydrophobic drug, loaded poly(epsilon-caprolactone)poly(ethylene glycol)-poly(epsilon-caprolactone) (PCEC) nanoparticles were prepared by emulsion solvent evaporation method, and then were incorporated into thermo-sensitive F127 hydrous matrix. The obtained injectable hydrophobic drug delivery system can act as a depot for sustained release of honokiol in situ. The lower critical solution temperature (LCST) of the composite matrix increases with increase in the mass of incorporated nanoparticles, or with decrease in the amount of residual organic solvent in the system. Honokiol release profile in vitro was studied, and the results showed that honokiol could be sustained released from the system. The described injectable drug delivery system might have great potential application for local delivery of hydrophobic drugs such as honokiol. (C) 2008 Elsevier B.V. All rights reserved.