Population growth of human Y chromosomes: A study of Y chromosome microsatellites
Population growth of human Y chromosomes: A study of Y chromosome microsatellites
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DOI：
10.1093/oxfordjournals.molbev.a026091
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发表时间：
1999-12-01
影响因子：
10.7
通讯作者：
Feldman, MW
中科院分区：
文献类型：
--
作者：
Pritchard, JK;Seielstad, MT;Feldman, MW
我们利用一组8个人类Y染色体微卫星基因座的变异来研究Y染色体的人口学历史。我们不是像大多数以前的Y染色体研究中那样假设人口大小不变，而是考虑了一个允许最近一段时间人口增长的模型。我们表明，对于我们样本中的大多数人口，该模型比没有增长的模型对数据的拟合要好得多。我们估计了每个人口模型的人口学参数，以及到最近共同祖先的时间。由于微卫星突变过程的细节存在一些不确定性，我们考虑了几种可能的突变方案，并同时估计了突变大小的方差和感兴趣的人口统计学参数。我们发现了一个最近的共同祖先(可能是在过去的12万年)，再加上所有人口都有人口扩张的强烈信号，这表明要么是最近人类从一个很小的祖先人口扩张，要么是作用于Y染色体的自然选择。
We use variation at a set of eight human Y chromosome microsatellite loci to investigate the demographic history of the Y chromosome. instead of assuming a population of constant size, as in most of the previous work on the Y chromosome, we consider a model which permits a period of recent population growth. We show that for most of the populations in our sample this model fits the data far better than a model with no growth. We estimate the demographic parameters of this model for each population and also the time to the most recent common ancestor. Since there is some uncertainty about the details of the microsatellite mutation process, we consider several plausible mutation schemes and estimate the variance in mutation size simultaneously with the demographic parameters of interest. Our finding of a recent common ancestor (probably in the last 120,000 years), coupled with a strong signal of demographic expansion in all populations, suggests either a recent human expansion from a small ancestral population, or natural selection acting on the Y chromosome.