Synthesis, swelling and drug release behavior of poly(N,N-diethylacrylamide-co-N-hydroxymethyl acrylamide) hydrogel
Synthesis, swelling and drug release behavior of poly(N,N-diethylacrylamide-co-N-hydroxymethyl acrylamide) hydrogel
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DOI：
10.1016/j.msec.2009.04.008
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发表时间：
2009-08-31
影响因子：
7.9
通讯作者：
Ma, Liwei
中科院分区：
文献类型：
--
作者：
Chen, Jun;Liu, Mingzhu;Ma, Liwei
本研究通过改变初始DEA/NHMAA的摩尔比、N，N′-亚甲基双丙烯酰胺和总单体浓度，合成了聚（N，N-二乙基丙烯酰胺-co-N-羟甲基丙烯酰胺）（聚（DEA-co-NHMAA））水凝胶。通过改变上述参数，优化了材料的热敏性能和力学性能。利用傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM）对水凝胶进行了表征。与PDEA水凝胶相比，随着饲料中NHMAA含量的增加，水凝胶的平衡溶胀比（ESR）和下临界溶解温度（LCST）均有所提高。研究了溶胀动力学。模型药物氨茶碱的释放行为依赖于水凝胶的组成和环境温度，这表明这些材料作为智能药物载体具有潜在的应用前景。(C) 2009 Elsevier B.V.版权所有
In this study, poly(N,N-diethylacrylamide-co-N-hydroxymethyl acrylamide) (poly(DEA-co-NHMAA)) hydrogels were synthesized by changing the initial DEA/NHMAA mole ratio, N,N'-methylenebisacrylamide and total monomer concentration. The thermosensitive and mechanical performances were optimized by altering the above parameters. The hydrogels were characterized by using Fourier transform infrared (FTIR) spectroscope and scanning electron microscope (SEM). In comparison with the PDEA hydrogel, the equilibrium swelling ratio (ESR) and lower critical solution temperature (LCST) of the hydrogels increased with the increase of NHMAA content in the feed. The swelling kinetics was also studied. The release behaviors of the model drug, aminophylline, are found dependent on hydrogel composition and environmental temperature, which suggests that these materials have potential application as intelligent drug carriers. (C) 2009 Elsevier B.V. All rights reserved.