Natural Product Discovery by Direct Analysis in Real Time Mass Spectrometry.
Natural Product Discovery by Direct Analysis in Real Time Mass Spectrometry.
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通过直接分析在实时质谱法中发现自然产品。
DOI：
10.5702/massspectrometry.s0081
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yew JY
中科院分区：
文献类型：
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作者：
Yew JY
直接分析实时质谱（DART MS）是最早被引入和商业化的环境电离方法之一。分析DART MS需要最少的样品制备，产生几乎即时的结果，并提供检测范围广泛的化合物。这些有利的特征特别适合于天然产物分析的固有复杂性。本文综述了DART MS在植物、昆虫、微生物和生物系统代谢物的化学分类、化学谱分析、遗传筛选和化学空间分析等方面的最新应用。
Direct analysis in real time mass spectrometry (DART MS) is one of the first ambient ionization methods to be introduced and commercialized. Analysis by DART MS requires minimal sample preparation, produces nearly instantaneous results, and provides detection over a broad range of compounds. These advantageous features are particularly well-suited for the inherent complexity of natural product analysis. This review highlights recent applications of DART MS for species identification by chemotaxonomy, chemical profiling, genetic screening, and chemical spatial analysis from plants, insects, microbes, and metabolites from living systems.