Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota
Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota
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DOI：
10.3390/md17080455
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发表时间：
2019-08-01
期刊：
影响因子：
5.4
通讯作者：
Yang, Huicheng
中科院分区：
文献类型：
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作者：
Hu, Shiwei;Xu, Yangli;Yang, Huicheng
本研究评价了海参长链碱基（SC-LCB）对高脂饮食喂养小鼠肠道微生物群的调节和肥胖抑制的作用。结果表明，SC-LCB具有显著的减肥作用，其作用机制与抑制高血糖和脂质蓄积有关。SC-LCB还调节血清脂肪细胞因子向正常水平。SC-LCB引起厚壁菌门、放线菌门和肥胖相关细菌（脱硫菌、双歧杆菌、Romboutsia等属）的显著减少。SC-LCB还增加拟杆菌门、变形菌门、疣微菌门和短链脂肪酸（SCFA）产生细菌（拟杆菌属、乳杆菌属、毛螺菌科_NK4A136_group等属）。此外，血清和粪便脂多糖（LPS）浓度及其依赖的Toll线受体4途径被SC-LCB处理抑制。SC-LCB导致粪便SCFA及其介导的G蛋白偶联受体蛋白增加。这表明SC-LCB通过改变肠道微生物群来减轻肥胖。因此，它试图表明SC-LCB可以被开发为用于肥胖控制和人类肠道健康的食品补充剂。
This study evaluated the effects of long-chain bases from sea cucumber (SC-LCBs) on modulation of the gut microbiota and inhibition of obesity in high fat diet-fed mice. Results showed that SC-LCBs exerted significant antiobese effects, which were associated with the inhibition of hyperglycemia and lipid accumulation. SC-LCBs also regulated serum adipocytokines toward to normal levels. SC-LCBs caused significant decreases in Firmicutes, Actinobacteria phylum, and obesity-related bacteria (Desulfovibro, Bifidobacterium, Romboutsia etc. genus). SC-LCBs also elevated Bacteroidetes, Proteobacteria, Verrucomicrobia phylum, and short chain fatty acids (SCFAs)-producing bacteria (Bacteroides, Lactobacillus, Lachnospiraceae_NK4A136_group etc. genus). Moreover, serum and fecal lipoplysaccharide (LPS) concentrations and its dependent toll-line receptor 4 pathway were inhibited by SC-LCBs treatment. SC-LCBs caused increases in fecal SCFAs and their mediated G-protein-coupled receptors proteins. These suggest that SC-LCBs alleviate obesity by altering gut microbiota. Thus, it sought to indicate that SC-LCBs can be developed as food supplement for the obesity control and the human gut health.