ENZYMES IN ORGANIC-SYNTHESIS .2. ONE-POT SYNTHESIS OF TAGATOSE 1,6-BISPHOSPHATE BY DIASTEREOSELECTIVE ENZYMATIC ALDOL ADDITION
ENZYMES IN ORGANIC-SYNTHESIS .2. ONE-POT SYNTHESIS OF TAGATOSE 1,6-BISPHOSPHATE BY DIASTEREOSELECTIVE ENZYMATIC ALDOL ADDITION
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DOI：
10.1002/anie.199200561
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发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
EYRISCH, O
中科院分区：
文献类型：
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作者：
FESSNER, WD;EYRISCH, O
从E. D-塔格糖-1，6-二磷酸-醛缩酶（TagA）是一种高效合成D-塔格糖二磷酸的酶，催化磷酸二羟丙酮与3-磷酸甘油醛的不对称加成反应。 作为少量副产物形成的4-差向异构体可以通过随后的特定酶促反应容易地从产物混合物中除去。
A new aldolase from E. coli, the D-tagatose-1,6-bisphosphate-aldolase (TagA), catalyzes the asymmetric addition of dihydroxyacetone phosphate to D-glycerinaldehyde-3-phosphate, which can be used for the efficient synthesis of the bisphosphate 1 of the rare carbohydrate metabolite D-tagatose. A 4-epimer formed as a byproduct in small amounts can be removed easily from the mixture of products by subsequent specific enzymatic reactions.