Maternal hepatitis B and hepatitis C carrier status and perinatal outcomes
Maternal hepatitis B and hepatitis C carrier status and perinatal outcomes
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DOI：
10.1111/j.1478-3231.2011.02556.x
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发表时间：
2011-09-01
影响因子：
6.7
通讯作者：
Mbah, Alfred K.
中科院分区：
文献类型：
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作者：
Connell, Laura E.;Salihu, Hamisu M.;Mbah, Alfred K.
背景和目的：在佛罗里达州调查母体乙肝和丙型肝炎单一和联合感染与单胎妊娠结局的关系。方法：我们使用与出院数据相关联的出生证明记录分析了1998至2007年间所有佛罗里达州出生的婴儿。感兴趣的主要结局是选定的妊娠结局，包括早产、低出生体重(LBW)、小于胎龄(SGA)、胎儿窘迫、新生儿黄疸和先天性异常。结果：研究样本包括1 670 369条记录。人类免疫缺陷病毒合并感染和各种形式的药物滥用在感染乙型和丙型肝炎的母亲中更为常见。在使用多变量模型调整重要的社会人口学变量和产科并发症后，感染丙型肝炎的妇女更有可能早产[优势比(OR)，1.40；95%可信区间(CI)，1.15-1.72]、低出生体重(OR，1.39；95%CI，1.11-1.74)和先天性畸形(OR，1.55；95%CI，1.14-2.11)。此外，感染乙肝病毒的妇女生下SGA婴儿的可能性较小(OR，0.79；95%CI，0.66-0.95)。结论：我们的研究结果进一步了解了母体乙肝或丙型肝炎携带者状态与围产儿结局之间的关系。感染丙型肝炎的妇女所生的婴儿似乎面临着不良出生结局的风险，包括早产、LBW和先天性畸形。
Background and aims: To examine the association between maternal hepatitis B and C mono- and co-infections with singleton pregnancy outcomes in the state of Florida. Methods: We analysed all Florida births from 1998 to 2007 using birth certificate records linked to hospital discharge data. The main outcomes of interest were selected pregnancy outcomes including preterm birth, low birth weight (LBW), small for gestational age (SGA), fetal distress, neonatal jaundice and congenital anomaly. Results: The study sample consisted of 1 670 369 records. Human immunodeficiency virus co-infection and all forms of substance abuse were more frequent in mothers with hepatitis B and C infection. After using multivariable modelling to adjust for important socio-demographical variables and obstetric complications, women with hepatitis C infection were more likely to have infants born preterm [odds ratio (OR), 1.40; 95% confidence intervals (CI), 1.15-1.72], with LBW (OR, 1.39; 95% CI, 1.11-1.74) and congenital anomaly (OR, 1.55; 95% CI, 1.14-2.11). In addition, women with hepatitis B infection were less likely to have infants born SGA (OR, 0.79; 95% CI, 0.66-0.95). Conclusions: Our findings provide further understanding of the association between maternal hepatitis B or C carrier status and perinatal outcomes. Infants born to women with hepatitis C infection appear to be at risk for poor birth outcomes, including preterm birth, LBW and congenital anomaly.