An environmental wide association study (EWAS) approach to the metabolic syndrome
An environmental wide association study (EWAS) approach to the metabolic syndrome
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DOI：
10.1016/j.envint.2013.01.017
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发表时间：
2013-05-01
影响因子：
11.8
通讯作者：
Lind, Lars
中科院分区：
文献类型：
--
作者：
Lind, P. Monica;Riserus, Ulf;Lind, Lars
背景：环境污染物以前与代谢综合征（MetS）的组成部分有关。然而，接触环境污染物在一定程度上是由各种生活方式因素决定的。目的：通过一项综合环境污染物和生活方式因素的“全环境关联研究”（ELWAS），我们旨在评估污染物和生活方式因素对MetS可能的附加作用。方法：在乌普萨拉老年人血管系统前瞻性调查（PIVUS）研究中，对1016名70岁的老年人进行调查。在循环中测量了43种环境污染物。利用饮食记录对21种营养素进行评价，并测定13种脂肪酸在血清胆固醇酯中的比例，进一步量化脂肪质量摄入量。加上其他5个重要的生活方式因素，总共有76个环境和生活方式因素。MetS由NCEP/ atpiii标准定义。结果：23%的患者有MetS。在样本中使用交叉验证，14种环境污染物或生活方式因素一致显示错误的发现率
Background: Environmental contaminants have previously been linked to components of the Metabolic Syndrome (MetS). However, exposure to environmental contaminants is in part determined by various lifestyle factors.Objective: Using an "Environmental Wide Association Study" (ELWAS) integrating environmental contaminants and lifestyle factors, we aimed to evaluate a possible additive role of both contaminants and lifestyle factors regarding MetS.Methods: 1016 subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. 43 environmental contaminants were measured in the circulation. Dietary records were used to evaluate 21 nutrients and the proportions of 13 fatty acids were determined in serum cholesterol esters to further quantify fat quality intake. Adding 5 other important lifestyle factors yielded together 76 environmental and lifestyle factors. MetS was defined by the NCEP/ATPIII-criteria.Results: 23% had MetS. Using cross-validation within the sample, fourteen environmental contaminants or lifestyle factors consistently showed a false discovery rate