Cancer Cachexia and MicroRNAs.
Cancer Cachexia and MicroRNAs.
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DOI：
10.1155/2015/367561
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发表时间：
2015
影响因子：
4.6
通讯作者：
Seelaender M
中科院分区：
文献类型：
--
作者：
Camargo RG;Quintas Teixeira Ribeiro H;Geraldo MV;Matos-Neto E;Neves RX;Carnevali LC Jr;Donatto FF;Alcântara PS;Ottoch JP;Seelaender M
癌症恶病质是一种影响生活质量和生存的副肿瘤综合征，主要表现为不自主的体重减轻、疲劳和全身炎症。该综合征被描述为肿瘤-宿主相互作用的结果，其特征是宿主对肿瘤的存在产生炎症反应。事实上，全身性炎症被认为是恶病质进展和维持的关键特征。细胞因子与慢性全身性炎症密切相关，这些因子的释放机制尚未完全阐明，恶病质的病因尚不完全清楚。因此，了解恶病质相关机制，建立该综合征的标志物是非常重要的。MicroRNAs （miRNAs）是一类干扰基因调控的非编码rna。不同的miRNA表达谱与不同的疾病和炎症过程相关。mirna调节癌症恶病质中的脂肪和骨骼肌组织代谢以及肿瘤和组织源性炎症。因此，我们提出了mirna在恶病质期间宿主炎症反应调节中的可能作用。此外，建立关于mirna和恶病质机制的强有力的证据是强制性的，并将有助于改善其诊断和治疗。
Cancer cachexia is a paraneoplastic syndrome compromising quality of life and survival, mainly characterized by involuntary weight loss, fatigue, and systemic inflammation. The syndrome is described as a result of tumor-host interactions characterized by an inflammatory response by the host to the presence of the tumor. Indeed, systemic inflammation is considered a pivotal feature in cachexia progression and maintenance. Cytokines are intimately related to chronic systemic inflammation and the mechanisms underlying the release of these factors are not totally elucidated, the etiology of cachexia being still not fully understood. Therefore, the understanding of cachexia-related mechanisms, as well as the establishment of markers for the syndrome, is very relevant. MicroRNAs (miRNAs) are a class of noncoding RNAs interfering with gene regulation. Different miRNA expression profiles are associated with different diseases and inflammatory processes. miRNAs modulate adipose and skeletal muscle tissue metabolism in cancer cachexia and also tumor and tissue derived inflammation. Therefore, we propose a possible role for miRNAs in the modulation of the host inflammatory response during cachexia. Moreover, the establishment of a robust body of evidence in regard to miRNAs and the mechanisms underlying cachexia is mandatory, and shall contribute to the improvement of its diagnosis and treatment.