Immunomodulators secreted from parasitic helminths act on pattern recognition receptors
Immunomodulators secreted from parasitic helminths act on pattern recognition receptors
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DOI：
10.3389/fpara.2022.1091596
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发表时间：
2023-01
期刊：
影响因子：
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通讯作者：
Daigo Tsubokawa
中科院分区：
文献类型：
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作者：
Daigo Tsubokawa
寄生蠕虫的排泄（ES）产物含有免疫调节分子，可以调节宿主的免疫反应。这些免疫调节分子对于成功寄生至关重要，并在组织迁移、成熟和繁殖中发挥作用。一些目标模式识别受体（PRR），包括Toll样受体、C型凝集素受体、晚期糖基化终产物受体和核苷酸结合寡聚化结构域样受体。 PRR 触发信号级联的激活，诱导宿主先天炎症反应和适应性免疫。本文综述了在寄生蠕虫中发现的作用于 PRR 的 ES 免疫调节剂及其 PRR 促进的免疫调节机制。此外，我们还描述了 ES 免疫调节剂对过敏性和炎症性疾病的治疗潜力。
Excretory-secretory (ES) products from parasitic helminths contain immunomodulatory molecules, which can regulate host immune responses. These immunomodulatory molecules are crucial for successful parasitism, and play roles in tissue migration, maturation, and reproduction. Some target pattern recognition receptors (PRRs), including toll-like receptor, C-type lectin receptor, receptor for advanced glycation end products, and nucleotide-binding oligomerization domain-like receptor. PRRs trigger activation of signaling cascades, inducing innate inflammatory responses and adaptive immunity in hosts. This article reviews ES immunomodulators identified in parasitic helminths that act on PRRs, and their PRR-facilitated immune-regulatory mechanisms. In addition, we describe the therapeutic potential of ES immunomodulators for allergic and inflammatory diseases.