GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) - THE MAJOR PROTEIN OF GLIAL INTERMEDIATE FILAMENTS IN DIFFERENTIATED ASTROCYTES
GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) - THE MAJOR PROTEIN OF GLIAL INTERMEDIATE FILAMENTS IN DIFFERENTIATED ASTROCYTES
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DOI：
10.1016/s0165-5728(85)80063-1
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
ENG, LF
中科院分区：
文献类型：
--
作者：
ENG, LF
胶质细胞酸性蛋白（GFAP）是中枢神经系统星形胶质细胞分化的纤维和原生质中胶质中间丝的主要蛋白成分。在神经嵴和外胚层起源的细胞中发现了具有类似MW、等电点和与GFAP免疫反应性的蛋白质。一个假定的功能归因于胶质纤维是其作为细胞骨架的一个组成部分，在确定和维持星形胶质细胞的形状的作用。自1980年以来，已有> 350篇报道利用GFAP抗血清进行免疫化学和免疫细胞化学研究。
The glial fibrillary acidic protein (GFAP) is the major protein constituent of glial intermediate filaments in differentiated fibrous and protoplasmic astrocytes of the CNS. Proteins having similar MW, isoelectric points, and immunoreactivity with GFAP have been found in cells of neural crest and ectodermal origin. A putative function ascribed to glial filaments is its role as a component of the cytoskeleton in defining and maintaining the shape of the astrocyte. Since 1980, > 350 reports have utilized antisera to GFAP for immunochemical and immunocytochemical studies.