Behavioral training enhances cortical temporal processing in neonatally deafened juvenile cats
Behavioral training enhances cortical temporal processing in neonatally deafened juvenile cats
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DOI：
10.1152/jn.00731.2010
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发表时间：
2011-08-01
影响因子：
2.5
通讯作者：
Schreiner, Christoph E.
中科院分区：
文献类型：
--
作者：
Beitel, Ralph E.;Vollmer, Maike;Schreiner, Christoph E.
Beitel RE, Vollmer M, Raggio MW, Schreiner CE。行为训练增强初生失聪幼猫皮层颞叶加工。[J] .中国生物医学工程学报，2016,31(4):559 - 559。首次发表于2011年5月4日；doi: 10.1152 / jn.00731.2010。植入人工耳蜗的聋人主要依靠时间线索进行语音识别，因为频谱信息处理严重受损。在语音感知出现改善之前，通常需要使用人工耳蜗进行训练，这表明相关经验改变了中央听觉系统的时间处理。我们通过比较只接受慢性被动耳蜗内电刺激（ICES）的猫的初级听觉皮层（AI）的时间加工，与接受ICES训练以检测时间挑战性电脉冲序列的猫的初级听觉皮层（AI），在新生失聪猫中验证了这一假设。经过几个月的慢性被动刺激和几周的行为训练后，在麻醉动物中记录了由暂时调制的ICES引起的多神经元人工智能反应。在行为训练的猫中，产生最大锁相尖峰数（最佳重复率）的刺激重复率和50%的切断率显著高于只接受慢性被动ICES的猫。行为训练将神经元颞叶跟随能力恢复到与早期正常听力的成年失聪动物相当的水平。重要的是，在行为训练中使用的电极配置激活的神经元簇中，最佳重复率和切断率最高。这些结果表明，在发育过程中被剥夺普通听觉经验的动物，行为训练和知觉学习诱导了人工智能的神经可塑性，并表明行为训练可以改善或恢复深度失聪动物的人工智能的时间加工。
Beitel RE, Vollmer M, Raggio MW, Schreiner CE. Behavioral training enhances cortical temporal processing in neonatally deafened juvenile cats. J Neurophysiol 106: 944-959, 2011. First published May 4, 2011; doi:10.1152/jn.00731.2010.-Deaf humans implanted with a cochlear prosthesis depend largely on temporal cues for speech recognition because spectral information processing is severely impaired. Training with a cochlear prosthesis is typically required before speech perception shows improvement, suggesting that relevant experience modifies temporal processing in the central auditory system. We tested this hypothesis in neonatally deafened cats by comparing temporal processing in the primary auditory cortex (AI) of cats that received only chronic passive intracochlear electric stimulation (ICES) with cats that were also trained with ICES to detect temporally challenging trains of electric pulses. After months of chronic passive stimulation and several weeks of detection training in behaviorally trained cats, multineuronal AI responses evoked by temporally modulated ICES were recorded in anesthetized animals. The stimulus repetition rates that produced the maximum number of phase-locked spikes (best repetition rate) and 50% cutoff rate were significantly higher in behaviorally trained cats than the corresponding rates in cats that received only chronic passive ICES. Behavioral training restored neuronal temporal following ability to levels comparable with those recorded in naive prior normal-hearing adult deafened animals. Importantly, best repetitition rates and cutoff rates were highest for neuronal clusters activated by the electrode configuration used in behavioral training. These results suggest that neuroplasticity in the AI is induced by behavioral training and perceptual learning in animals deprived of ordinary auditory experience during development and indicate that behavioral training can ameliorate or restore temporal processing in the AI of profoundly deaf animals.