Salivary levels of tumor necrosis factor-alpha in oral lichen planus.
Salivary levels of tumor necrosis factor-alpha in oral lichen planus.
复制标题
DOI：
10.1080/09629350410001688530
复制
发表时间：
2004-04
影响因子：
4.6
通讯作者：
Simunovic-Soskic, Marica
中科院分区：
文献类型：
--
作者：
Pezelj-Ribaric, Sonja;Prso, Ivana Brekalo;Abram, Maja;Glazar, Irena;Brumini, Gordana;Simunovic-Soskic, Marica
目的：口腔扁平苔藓（OLP）是口腔粘膜的慢性炎症性疾病，临床表现多样。口腔扁平苔藓的病因仍然是未知的，但越来越多的证据表明，这种疾病的免疫学基础。目的：我们的研究是为了量化唾液中促炎性肿瘤坏死因子-α（TNF-α）在网状和糜烂/萎缩型OLP中的水平，并与年龄匹配的健康对照志愿者进行比较。受试者和方法：采用酶免疫分析法对40例OLP活动性病变患者和20例健康人的全唾液中TNF-α的存在进行了研究。结果：与健康受试者相比，OLP患者的唾液TNF-α水平显著升高。TNF-α的存在与OLP的临床形式呈正相关，在糜烂/萎缩型中显著高于网状型疾病。结论：唾液是检测口腔炎症标志物的理想介质。在OLP患者中，唾液中的TNF-α水平升高，与疾病的严重程度相关。唾液TNF-α分析可能是一个有用的诊断工具，并在OLP的一个潜在的预后指标。
OBJECTIVE: Oral lichen planus (OLP) is chronic inflammatory disease of the oral mucosa, presenting in various clinical forms. The etiology of OLP is still unknown but mounting evidence points to the immunologic basis of this disorder. AIM: Our study was undertaken to quantify the salivary levels of pro-inflammatory tumor necrosis factor-alpha (TNF-alpha) in the reticular and the erosive/atrophic forms of OLP, compared with age-matched healthy control volunteers. SUBJECTS AND METHODS: Whole saliva from 40 patients with active lesions of OLP, as well as from 20 healthy persons, was investigated for the presence of TNF-alpha by enzyme immunoassay. RESULTS: Salivary TNF-alpha levels were significantly increased in patients with OLP in comparison with healthy subjects. The presence of TNF-alpha showed positive correlation to clinical forms of OLP, being significantly higher in the erosive/atrophic type than in the reticular type of disease. CONCLUSION: Saliva provides an ideal medium for the detection of pro-inflammatory markers of the oral cavity. In patients with OLP, TNF-alpha levels in saliva are elevated, correlating with the severity of illness. Salivary TNF-alpha analysis may be a useful diagnostic tool and a potential prognostic marker in OLP.