COGNITIVE AND MOTOR SHIFTING APTITUDE DISORDER IN PARKINSONS-DISEASE
COGNITIVE AND MOTOR SHIFTING APTITUDE DISORDER IN PARKINSONS-DISEASE
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DOI：
10.1136/jnnp.47.5.443
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发表时间：
1984-01-01
影响因子：
11
通讯作者：
BERGER, HJC
中科院分区：
文献类型：
--
作者：
COOLS, AR;VANDENBERCKEN, JHL;BERGER, HJC
18名帕金森氏病患者和19名年龄和智力相匹配的对照者，在认知和运动水平（单词生成、分类积木或动物和手指按压序列）上进行了能力转移测试的比较。与对照组相比，帕金森患者在1分钟内产生的不同动物和职业名称更少，需要更多的试验来检测分类标准的变化，并且在按压顺序的变化中产生的手指反应比对照组少。这些结果被解释为反映了一种中枢编程缺陷，这种缺陷在语言、图形和运动模式中表现出来，即基底神经节功能障碍患者的移动能力减弱。研究结果与基底节区功能障碍动物行为组织的变化有关。
Patients (18) suffering from Parkinson''s disease and 19 control subjects, who were matched for age and intelligence, were compared in tests measuring shifting aptitude at cognitive and motor levels (word production, sorting blocks or animals and finger pushing sequences). Parkinson patients produced fewer different names of animals and professions in 1 min than control subjects, needed more trials for detecting a shift in a sorting criterion, and produced fewer finger responses in a change of pushing sequence than control subjects. These results are interpreted as reflecting a central programming deficit that manifests itself in verbal, figural and motor modalities, i.e., a diminished shifting aptitude characteristic of patients with dysfunctioning basal ganglia. The results are discussed in relation to changes of behavior organizations in animals with dysfunctioning basal ganglia.