Expression of developmentally regulated endothelial cell locus 1 was induced by tumor-derived factors including VEGF
Expression of developmentally regulated endothelial cell locus 1 was induced by tumor-derived factors including VEGF
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DOI：
10.1016/j.bbrc.2005.06.009
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发表时间：
2005-08-05
影响因子：
3.1
通讯作者：
Kimura, T
中科院分区：
文献类型：
--
作者：
Aoki, M;Kanamori, M;Kimura, T
发育调节内皮细胞基因座I(Del I)是一种新的血管生成分子，在早期胚胎内皮细胞中特异表达。我们研究了DELL与肿瘤细胞来源的血管内皮生长因子(VEGF)的关系。Dunn骨肉瘤细胞和高、低转移的小鼠肉瘤细胞均不表达DELL。皮下接种后，Del I在这些原发肿瘤组织和肺转移瘤组织中均有表达。每种含血管内皮生长因子的肿瘤细胞条件培养液均可诱导小鼠肺微血管内皮细胞表达DELL，而对照MLE细胞不表达DELI。抗小鼠血管内皮生长因子单抗抑制DELL表达。此外，小鼠重组白介素Lot和肿瘤坏死因子-α也可诱导MLE细胞发生DELL。戴尔可能通过包括血管内皮生长因子在内的肿瘤衍生因子的作用，在肿瘤血管生成中发挥重要作用。(C)2005 Elsevier Inc.保留所有权利。
Developmentally regulated endothelial cell locus I (Del I) is a new angiogenic molecules expressed specifically in early embryonic endothelial cells. We investigated the relationship between Dell and tumor cell-derived vascular endothelial growth factor (VEGF). Dunn osteosarcoma cells and high- and low-metastatic murine sarcoma cells did not express Dell. However, the expression of Del I was observed in these primary tumor tissues and the pulmonary metastatic tissues after subcutaneous inoculation in vivo. Every tumor cell-conditioned medium containing VEGF induced the expression of Dell in murine lung microvascular endothelial (MLE) cells, although control MLE cells did not express Del I. The anti-mouse VEGF monoclonal antibody inhibited the induction of the Dell expression. In addition, mouse recombinant interleukin-lot and tumor necrosis factor-alpha also induced Dell in MLE cells. Dell may play an important role in tumor angiogenesis through the effects of tumor-derived factors including VEGF. (c) 2005 Elsevier Inc. All rights reserved.