Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
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DOI：
10.1073/pnas.93.22.12445
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发表时间：
1996-10-29
影响因子：
11.1
通讯作者：
Spies, T
中科院分区：
文献类型：
--
作者：
Groh, V;Bahram, S;Spies, T
传统的主要组织相容性复合物 (MHC) I 类基因编码向 T 细胞呈递细胞内肽抗原的分子。它们普遍表达并受干扰素γ调节。两个高度分化的人类 MHC I 类基因 MICA 和 MICB 受到类似于 HSP70 基因的启动子热休克元件的调节。 MICA 编码一种细胞表面糖蛋白，不与 β(2)-微球蛋白相关，其构象稳定，独立于常规 I 类肽配体，并且几乎只在胃肠道上皮中表达。因此，这种 MHC I 类分子可能作为细胞应激的指示剂，并可能在不寻常的相互作用中被肠粘膜 T 细胞的子集识别。
Conventional major histocompatibility complex (MHC) class I genes encode molecules that present intracellular peptide antigens to T cells. They are ubiquitously expressed and regulated by interferon gamma. Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes. MICA encodes a cell surface glycoprotein, which is not associated with beta(2)-microglobulin, is conformationally stable independent of conventional class I peptide ligands, and almost exclusively expressed in gastrointestinal epithelium. Thus, this MHC class I molecule may function as an indicator of cell stress and may be recognized by a subset of gut mucosal T cells in an unusual interaction.