Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice
Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice
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DOI：
10.1007/bf02978260
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发表时间：
2001-06-01
影响因子：
6.7
通讯作者：
Park, SH
中科院分区：
文献类型：
--
作者：
Chung, SH;Choi, CG;Park, SH
对白色人参（Ginseng Radix Alba，GRA）和人参根（Ginseng Radix Palva，GRP）的抗糖尿病作用机制进行了研究。口服给药四周后，GRA和GRP治疗组的空腹血糖水平低于对照组。为了阐明人参根的降血糖机制，检查了小肠的葡萄糖吸收、肝己糖激酶和葡萄糖-6-磷酸酶活性以及脂肪组织中的PPAR-gamma表达。结果强烈表明，GRA可以改善KKAy小鼠的高血糖症，可能是通过阻断肠道葡萄糖吸收和抑制肝脏葡萄糖-6-磷酸酶，和GRP通过上调脂肪细胞PPAR-gamma蛋白表达以及抑制肠道葡萄糖吸收。
The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Ginseng Radix Palva, GRP) were investigated. After a four week oral administration, the fasting blood glucose levels in the GRA- and GRP-treated groups were lower when compared to the control group. To elucidate the hypoglycemic mechanism(s) of the ginseng radices, glucose absorption from the small intestine, hepatic hexokinase and glucose-6-phosphatase activities, in addition to PPAR-gamma expression in adipose tissue were Examined. The results strongly suggest that GRA can improve hyperglycemia in KKAy mice, possibly by blocking intestinal glucose absorption and inhibiting hepatic glucose-6-phosphatase, and GRP through the upregulation of adipocytic PPAR-gamma protein expression as well as inhibiting intestinal glucose absorption.