HIV Mono-infection Is Associated With FIB-4-A Noninvasive Index of Liver Fibrosis - in Women
HIV Mono-infection Is Associated With FIB-4-A Noninvasive Index of Liver Fibrosis - in Women
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DOI：
10.1093/cid/ciq199
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发表时间：
2011-03-01
影响因子：
11.8
通讯作者：
Sherman, Kenneth E.
中科院分区：
文献类型：
--
作者：
Blackard, Jason T.;Welge, Jeffrey A.;Sherman, Kenneth E.
背景。FIB-4是一种无创的复合指标，是一种有效的肝纤维化指标，是肝病的重要指标。迄今为止，关于女性肝纤维化的数据有限。FIB-4在1227名女性队列中进行了评估，并在按人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）感染状况分类的4组受试者中采用单因素和多因素回归模型评估了相关性。HIV-/HCV-女性FIB-4评分中位数为0.60，HIV-/HCV+女性为0.83，HIV+/HCV-女性为0.86，HIV+/HCV+女性为1.30。在HIV/HCV共感染组中，多因素分析显示CD4（+）细胞计数和白蛋白水平与FIB-4评分呈负相关（P < 0.0001），而抗逆转录病毒治疗（ART）与FIB-4评分呈正相关（P = 0.0008）。对于HIV单感染组，多变量分析显示CD4（+）细胞计数(P
Background. FIB-4 represents a noninvasive, composite index that is a validated measure of hepatic fibrosis, which is an important indicator of liver disease. To date, there are limited data regarding hepatic fibrosis in women.Methods. FIB-4 was evaluated in a cohort of 1227 women, and associations were evaluated in univariate and multivariate regression models among 4 groups of subjects classified by their human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection status.Results. The median FIB-4 scores were 0.60 in HIV-/HCV- women, 0.83 in HIV-/HCV+ women, 0.86 in HIV+/HCV- women, and 1.30 in HIV+/HCV+ women. In the HIV/HCV co-infected group, multivariate analysis showed that CD4(+) cell count and albumin level were negatively associated with FIB-4 (P < .0001), whereas antiretroviral therapy (ART) was positively associated with FIB-4 score (P = .0008). For the HIV mono-infected group, multivariate analysis showed that CD4(+) cell count (P