Platelet-Mimicking Therapeutic System for Noninvasive Mitigation of the Progression of Atherosclerotic Plaques.
Platelet-Mimicking Therapeutic System for Noninvasive Mitigation of the Progression of Atherosclerotic Plaques.
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用于无创缓解动脉粥样硬化斑块进展的模拟血小板治疗系统
DOI：
10.1002/advs.202004128
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Ma Y;Ma Y;Gao M;Han Z;Jiang W;Gu Y;Liu Y
动脉粥样硬化斑块是心血管疾病的主要原因，并且仍然是早期干预动脉粥样硬化的治疗障碍。传统的临床策略往往受到手术相关并发症或长期给药效果不佳的限制。受血小板的斑块结合能力的启发，仿生光动力治疗系统被设计用于减缓动脉粥样硬化斑块的进展。该系统由包埋在血小板膜中的光敏剂负载的上转换纳米颗粒核心组成。血小板膜涂层有助于治疗系统特异性靶向巨噬细胞源性泡沫细胞（早期动脉粥样硬化斑块的标志和主要成分），这已通过体内荧光和单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）放射性核素成像得到确证。重要的是，SPECT/CT成像引导的体内光疗可加速斑块进展。进一步的免疫荧光分析显示泡沫细胞凋亡和炎症改善。这种仿生系统将斑块结合与放射性核素成像引导相结合，是一种新型、无创且有效的缓解动脉粥样硬化斑块进展的策略。受血小板早期动脉粥样硬化斑块结合能力的启发，仿生光动力学治疗系统被设计用于准确定位和非侵入性缓解动脉粥样硬化斑块的进展。这种仿生系统协同斑块结合和放射性核素成像引导，为减轻动脉粥样硬化斑块的进展提供了一种新的、无创的和有效的策略。
Atherosclerotic plaque is the primary cause of cardiovascular disorders and remains a therapeutic hurdle for the early intervention of atherosclerosis. Traditional clinical strategies are often limited by surgery‐related complications or unsatisfactory effects of long‐term drug administration. Inspired by the plaque‐binding ability of platelets, a biomimic photodynamic therapeutic system is designed to mitigate the progression of atherosclerotic plaques. This system is composed of photosensitizer‐loaded upconversion nanoparticle cores entrapped in the platelet membrane. The platelet membrane coating facilitates specific targeting of the therapeutic system to macrophage‐derived foam cells, the hallmark, and main component of early stage atherosclerotic plaques, which is firmly confirmed by in vivo fluorescent and single‐photon emission computed tomography/computed tomography (SPECT/CT) radionuclide imaging. Importantly, in vivo phototherapy guided by SPECT/CT imaging alleviates plaque progression. Further immunofluorescence analysis reveals foam cell apoptosis and ameliorated inflammation. This biomimic system, which combines plaque‐binding with radionuclide imaging guidance, is a novel, noninvasive, and potent strategy to mitigate the progression of atherosclerotic plaque. Inspired by the early stage atherosclerotic plaque‐binding ability of platelets, a biomimic photodynamic therapeutic system is designed to accurately localize and noninvasively mitigate the progression of atherosclerotic plaques. This biomimic system synergizes plaque‐binding and radionuclide imaging guidance, providing a novel, noninvasive, and potent strategy for mitigating the progression of atherosclerotic plaque.