Progesterone in saliva does not parallel unbound progesterone in plasma.
Progesterone in saliva does not parallel unbound progesterone in plasma.
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唾液中的孕酮与血浆中未结合的孕酮不同。
DOI：
10.1093/clinchem/32.3.542
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发表时间：
1986
影响因子：
9.3
通讯作者：
J. Evans
中科院分区：
文献类型：
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作者：
J. Evans
为了评估唾液黄体酮的潜在应用，根据已发表的有关血液黄体酮的大量信息，我比较了配对样本中的血浆和唾液黄体酮，发现它们表现出相似的模式，两者在周期的后半段都具有高浓度。然而，血浆和唾液值之间的比率在循环过程中发生了变化。我观察到孕酮与血浆蛋白的结合没有伴随变化，如果唾液中的浓度反映了血浆中非蛋白结合类固醇的浓度，这可能是预期的。唾液蛋白对孕酮有一定的结合，但如此结合的孕酮比例在周期中显然保持恒定。因此，必须在了解唾液特性的情况下解释唾液中孕酮的数据，而不仅仅是“游离”血浆孕酮。
To assess the potential application of salivary progesterone, in light of the voluminous published information on blood progesterone, I compared plasma and salivary progesterone in paired samples and found that they exhibit similar patterns, both having high concentrations in the second half of the cycle. However, the ratio between values for plasma and saliva changed during the cycle. I observed no concomitant changes in binding of progesterone to plasma proteins, which might have been expected if the concentrations in saliva reflect those of non-protein-bound steroid in plasma. There was some binding of progesterone by salivary proteins, but the proportion of progesterone so bound apparently remained constant during the cycle. Data on progesterone in saliva must therefore be interpreted with awareness of the properties of saliva, and not simply as "free" plasma progesterone.