Elevated expression of ABCB5 in ocular surface squamous neoplasia.
Elevated expression of ABCB5 in ocular surface squamous neoplasia.
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DOI：
10.1038/srep20541
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发表时间：
2016-02-04
影响因子：
4.6
通讯作者：
Kinoshita S
中科院分区：
文献类型：
--
作者：
Jongkhajornpong P;Nakamura T;Sotozono C;Nagata M;Inatomi T;Kinoshita S
ATP结合盒亚家族B成员5（ABCB 5）是ATP结合盒超家族的新成员，被认为是角膜缘干细胞（LSC）的新标志物。在含有癌症干细胞（CSC）的几种癌细胞亚群中也发现了ABCB 5表达。然而，LSC与CSC和ABCB 5在眼表鳞状细胞肿瘤（OSSN）中的发病关系仍然完全未知。为了提高对ABCB5在OSSN中作用的理解，我们对9例OSSN病例系列中的ABCB5进行了免疫组化。虽然ABCB 5的表达仅限于正常利姆布斯的基底上皮细胞层，但在所有OSSN中清楚地观察到ABCB 5的表达升高，并且在ABCB 5表达的强度范围内存在一定的宽度。有趣的是，ABCB 5在OSSN中的表达升高模式可分为三类：血管周围型、边缘型和弥漫型。我们的研究结果首次证实了ABCB 5在OSSN中的表达上调，ABCB 5的高表达可能参与了OSSN的发病机制。
ATP-binding cassette subfamily B member 5 (ABCB5) is a new member of the ATP-binding cassette superfamily and has been reported as a novel marker for limbal stem cell (LSC), which is essential for corneal homeostasis. ABCB5 expression has also been discovered in the subpopulation of several cancer cells containing the cancer stem cell (CSC). However, the pathogenetic relationship between LSC and CSC and ABCB5 in the ocular surface squamous neoplasm (OSSN) is still entirely unknown. To improve understanding of the role of ABCB5 in OSSN, we performed immunohistochemistry for ABCB5 in nine OSSN case series. While expression of ABCB5 is restricted to the basal epithelial cell layer in the normal limbus, elevated expressions of ABCB5 were clearly observed in all OSSN, and there was some breadth in the range of intensity of ABCB5 expression. Interestingly, the elevated expression patterns of ABCB5 in OSSN could be classified in three categories: perivascular, marginal and diffuse patterns. Our findings demonstrated for the first time that the expression of ABCB5 was upregulated in OSSN and that elevated expression of ABCB5 may be involved in the pathogenesis of OSSN.