Sleep Variability, Sleep Irregularity, and Nighttime Blood Pressure Dipping.
Sleep Variability, Sleep Irregularity, and Nighttime Blood Pressure Dipping.
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睡眠变异、睡眠不规律和夜间血压下降。
DOI：
10.1161/hypertensionaha.123.21497
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Wang,Xiaoling
中科院分区：
文献类型：
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作者：
Xu,Yanyan;Barnes,VernonA;Harris,RyanA;Altvater,Michelle;Williams,Celestine;Norland,Kimberly;Looney,Jacob;Crandall,Reva;Su,Shaoyong;Wang,Xiaoling
背景昼夜节律调节人类许多重要的生物功能。本研究的目的是探讨睡眠-觉醒周期的日间偏差对夜间血压 (BP) 下降的影响，并进一步检验睡眠模式日间偏差的种族差异是否可以解释夜间血压下降的种族差异。方法从 365 名成年参与者（年龄范围为 18.7-50.1 岁； 52.6% 为黑人参与者，47.3% 为欧洲裔美国人；64.1% 为女性）。收缩压下降水平用于代表夜间血压下降。计算睡眠持续时间的标准差作为睡眠变异性指标，计算睡眠中点的标准差作为睡眠不规律的指标。结果睡眠中点标准差增加1小时，夜间血压下降1.16%（P<0.001）。睡眠时间标准差增加 1 小时与夜间血压下降 1.39% 相关（P=0.017）。睡眠中点标准差的种族差异可以解释 29.2% 血压下降的种族差异 (P=0.008)。 结论 在一般人群中，睡眠变异性和睡眠不规律与血压下降减弱有关。此外，本次调查的数据还表明，睡眠不规律的种族差异可以部分解释血压下降的种族差异，这一重要发现可能有助于缩小黑人参与者和欧洲裔美国人之间的健康差距。
BACKGROUNDCircadian rhythm regulates many important biological functions in humans. The goal of this study is to explore the impact of day-to-day deviations in the sleep-wake cycle on nighttime blood pressure (BP) dipping and further examine whether the ethnic difference in day-to-day deviations in sleep patterns can explain the ethnic difference in nighttime BP dipping.METHODSTwenty-four-hour ambulatory BP monitoring and 7-day accelerometer data were obtained from 365 adult participants (age range, 18.7–50.1 years; 52.6% Black participants and 47.3% European Americans; 64.1% females). Systolic BP dipping level was used to represent nighttime BP dipping. The SD of sleep duration was calculated as the index of sleep variability, and the SD of sleep midpoint was calculated as the index of sleep irregularity.RESULTSA 1-hour increase in the SD of sleep midpoint was associated with a 1.16% decrease in nighttime BP dipping (P<0.001). A 1-hour increase in the SD of sleep duration was associated with a 1.39% decrease in nighttime BP dipping (P=0.017). The ethnic difference in the SD of sleep midpoint can explain 29.2% of the ethnicity difference in BP dipping (P=0.008).CONCLUSIONSSleep variability and sleep irregularity are associated with blunted BP dipping in the general population. In addition, data from the present investigation also demonstrate that the ethnic difference in sleep irregularity could partly explain the ethnic difference in BP dipping, an important finding that may help reduce the health disparity between Black participants and European Americans.