Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey.
Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey.
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DOI：
10.1093/ajcn/73.5.927
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发表时间：
2001-05
期刊：
影响因子：
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通讯作者：
M. S. Morris;P. Jacques;I. Rosenberg;J. Selhub
中科院分区：
文献类型：
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作者：
M. S. Morris;P. Jacques;I. Rosenberg;J. Selhub
高循环总同型半胱氨酸（tHcy）浓度与卒中相关，卒中是认知功能障碍的主要原因。血液中同型半胱氨酸浓度与某些认知功能测试的表现呈负相关，最近发现高同型半胱氨酸血症与阿尔茨海默病之间存在相关性。目的评价参加第三次全国健康与营养调查第2阶段（1991- 1994）的老年男性和女性的血清tHcy浓度与短时延迟回忆测试成绩之间的关系。设计受试者年龄≥ 60岁。受试者报告以前没有中风，完成≥ 8年的教育，并进行了延迟回忆故事想法（n = 1200）或单词（n = 1270）的测试。结果：在调整性别、年龄、种族、收入、受教育年限和血清肌酐浓度后，叶酸水平分布上半部分的受试者平均回忆起6个故事中的4个;叶酸水平较低的受试者回忆起的故事明显较少（仅校正5个人口统计学因素后，3个先前学习的单词中的P或=1为0.3（95% CI：0.2，0.7），进一步校正血清叶酸浓度后为0.4（0.2，0.9）。结论高同型半胱氨酸血症与记忆力下降有关，这种关系部分独立于叶酸水平。
BACKGROUND High circulating total homocysteine (tHcy) concentrations are associated with stroke, which is a major cause of cognitive dysfunction. Blood homocysteine concentrations are inversely correlated with performance on some cognitive-function tests and a relation was recently shown between hyperhomocysteinemia and Alzheimer disease. OBJECTIVE The objective was to evaluate the relation between serum tHcy concentrations and performance on short delayed-recall tests of elderly men and women participating in the third National Health and Nutrition Examination Survey, phase 2 (1991--1994). DESIGN Subjects were aged > or =60 y. Subjects reported no previous stroke, completed > or =8 y of education, and took a test of delayed recall of story ideas (n = 1200) or words (n = 1270). RESULTS After adjustment for sex, age, race-ethnicity, income, years of education, and serum creatinine concentration, subjects in the upper half of the folate distribution recalled, on average, >4 of 6 story ideas; subjects with lower folate status recalled significantly fewer ideas (P or =1 of 3 previously learned words was 0.3 (95% CI: 0.2, 0.7) after adjustment for the 5 demographic factors alone and was 0.4 (0.2, 0.9) after further adjustment for serum folate concentration. CONCLUSION Hyperhomocysteinemia is related to poor recall and this association was partially independent of folate status.