Biology of Pericytes Recent Advances: Role of Pericytes in Brain Metastasis
Biology of Pericytes Recent Advances: Role of Pericytes in Brain Metastasis
复制标题
周细胞生物学最新进展：周细胞在脑转移中的作用
DOI：
10.1007/978-3-030-62129-2_3
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Matsuo Takayuki
中科院分区：
文献类型：
--
作者：
Morofuji Yoichi;Nakagawa Shinsuke;Fujimoto Takashi;Yamaguchi Susumu;Ujifuku Kenta;Matsuo Takayuki
脑转移瘤是临床上观察到的最常见的成人脑肿瘤，占所有脑肿瘤的一半以上。有效治疗脑转移性疾病的主要障碍是血脑屏障（BBB）。这种屏障将大多数化疗药物排除在脑外，并为转移性癌症创造了一个避难所。最近的研究提供了一些证据，表明星形胶质细胞通过与传入的癌细胞进行不同模式的相互作用在脑转移中发挥重要作用。相比之下，关于脑转移形成的潜在机制，特别是周细胞的作用知之甚少。在这篇综述中，我们讨论了最近的进展，我们的理解周细胞的生物学，特别是关于其在脑transferation.MethodsLiterature review.ResultsThe主要功能的周细胞是稳定的功能的血脑屏障。相比之下，癌细胞可以激活周细胞参与病理性血管生成，从而促进脑 转移进展。了解周细胞对细胞的刺激和抑制作用对揭示脑损伤的机制具有重要意义 结论周细胞可能是治疗和预防脑转移的关键细胞靶点 转移这些数据为周细胞的生物学及其在脑损伤发病机制中的潜在作用提供了新的见解。 转移这些发现应该刺激更多的研究，以更好地阐明周细胞促进大脑发育的机制。 转移和刺激针对这些细胞的治疗策略的发展。
IntroductionBrain metastases are the most common brain neoplasms observed clinically in adults, comprising more than half of all brain tumors.Brain metastaseshave been historically understudied, and they represent an emerging and urgent unmet medical need. The major impediment to effectively treating brain metastatic disease is the blood-brain barrier (BBB). This barrier excludes most chemotherapeutics from the brain and creates a sanctuary site for metastatic cancers. Recent studies have provided some evidence that astrocytes play a major role in brain metastasis by engaging different modes of interactions with incoming cancer cells. By contrast, little is known concerning the underlying mechanisms of brain metastasis formation, especially the role of pericytes. In this review, we discuss the recent advances in our understanding of the biology of pericytes, especially regarding its role in brain metastasis.MethodsLiterature review.ResultsThe primary function of pericytes is stabilizing the function of the BBB . By contrast, cancer cells can activate pericytes to participate in pathological angiogenesis and thus promote brain metastasis progression. It is important to understand both the stimulatory and inhibitory effects of pericytes on cells to reveal the mechanism of brain metastasis.ConclusionsBased on the findings of this review, pericytes could represent a key cellular target for the treatment and prevention of brain metastasis. These data provided new insights into the biology of pericytes and their potential roles in the pathogenesis of brain metastasis. These findings should spur additional studies to better clarify the mechanisms by which pericytes promote brain metastasis and stimulate the development of treatment strategies targeting these cells.