The NF-E2 transcription factor
The NF-E2 transcription factor
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DOI：
10.1016/s1357-2725(97)00135-0
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发表时间：
1998-04-01
影响因子：
4
通讯作者：
Andrews, NC
中科院分区：
文献类型：
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作者：
Andrews, NC
核因子-E2属于碱性亮氨酸拉链二聚体转录因子家族。它由一个广泛表达的与鸡Maf蛋白相关的18 kDa亚基和一个组织限制性的45 kDa亚基组成，该亚基含有一个CnD结构域。几乎只在造血祖细胞和红系/巨细胞/肥大细胞三联体细胞中发现。核因子-E2参与珠蛋白基因转录的调控，通过α和β珠蛋白基因簇上游的位置控制区(LCR)发挥作用。此外，它对正常的血小板生成也是必不可少的。定向破坏编码45 kDa亚基的基因会导致严重的血小板减少，但红细胞生成几乎没有缺陷，这表明其他分子可以取代P45在发育中的小鼠的红细胞成熟中。然而，逆转录病毒整合在p45基因内已被证明扰乱了红白血病细胞的红系分化；这表明，可以想象，p45可能是真性红细胞增多症患者的药物干预的靶点。(C)1998爱思唯尔科学有限公司。保留所有权利。
NF-E2 belongs to the basic-leucine zipper family of dimeric transcription factors. It consists of a widely expressed 18 kDa subunit, related to chicken Maf proteins, and a tissue-restricted 45 kDa subunit, which contains a cnc domain. It is found almost exclusively in hematopoietic progenitors, and cells of the erythroid/mega/mast cell trilineage. NF-E2 is involved in regulation of globin gene transcription, acting through locus control regions (LCRs) upstream of the alpha and beta globin gene clusters. In addition, it is essential for normal platelet production. Targeted disruption of the gene encoding the 45 kDa subunit leads to severe thrombocytopenia but little if any defect in erythropoiesis, indicating that other molecules can substitute for p45 in red cell maturation in developing mice. However, retroviral integration within the p45 gene has been shown to disrupt erythroid differentiation in erythroleukemia cells; this suggests that p45 could, conceivably, be a target for pharmacologic interventions in patients with excess red cell production due to polycythemia vera. (C) 1998 Elsevier Science Ltd. All rights reserved.