Quantitative Assessment of CYP1A1*2A Variations With Oral Carcinoma Susceptibility: Evidence From 1,438 Cases and 2,086 Controls
Quantitative Assessment of CYP1A1*2A Variations With Oral Carcinoma Susceptibility: Evidence From 1,438 Cases and 2,086 Controls
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DOI：
10.3109/07357907.2012.716470
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发表时间：
2012-09
影响因子：
2.4
通讯作者：
X. Zhuo;Houyu Zhao;A. Chang;Yan Zhou;Gang Zhang;Yufeng Song;Ying-hui Tan
中科院分区：
文献类型：
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作者：
X. Zhuo;Houyu Zhao;A. Chang;Yan Zhou;Gang Zhang;Yufeng Song;Ying-hui Tan
已发表的关于CYP1A1*2A（MspI）变异与口腔癌风险相关的证据产生了有争议的结果。我们之前在2008年的荟萃分析未能揭示CYP1A1*2A多态性与口腔癌易感性之间的显著关联。因此，进行了更新的荟萃分析。结果表明，CYP1A1*2A多态性与口腔癌风险之间存在显著相关性，这与我们之前的荟萃分析不一致。在按种族划分的亚组分析中，变异C等位基因可能会增加亚洲人而不是高加索人的口腔癌易感性。总之，结果表明，CYP1A1*2A多态性可能是一个低渗透的口腔癌的危险因素，特别是在亚洲人。
Published evidence concerning association of CYP1A1*2A (MspI) variation with oral carcinoma risk has generated controversial results. Our previous meta-analysis in 2008 failed to reveal a marked association between CYP1A1*2A polymorphism and oral cancer susceptibility. Therefore, updated meta-analyses were conducted. Results suggested significant associations between CYP1A1*2A polymorphisms and oral carcinoma risk for the overall data, inconsistent with our previous meta-analysis. In subgroup analyses by ethnicity, variant C allele might elevate oral cancer susceptibility among Asians but not Caucasians. In conclusion, results suggest that CYP1A1*2A polymorphism might be a low-penetrant risk factor for oral carcinoma, particularly among Asians.