Indirect evidence for decreased hypothalamic somatostatinergic tone in anorexia nervosa

Indirect evidence for decreased hypothalamic somatostatinergic tone in anorexia nervosa
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神经性厌食症下丘脑生长抑素能张力降低的间接证据

DOI:
10.1046/j.1365-2265.2002.01485.x
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发表时间:
2002
影响因子:
3.2
通讯作者:
Claus Hagen
Claus Hagen
中科院分区:
医学3区
文献类型:
--
作者:
René K. Støving;Marianne Andersen;A. Flyvbjerg;Jan Frystyk;J. Hangaard;Jørgen Vinten;O. Koldkjær;Claus Hagen

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在动物中,生长抑素(SRIH)和生长激素(GH)释放激素(GHRH)通过共同的神经机制增加摄食。此外,SRIH抵消了促肾上腺皮质激素释放激素(CRH)对食物摄入的抑制作用。推测SRIH可能参与神经性厌食症(anorexia nervosa,AN)的中枢摄食机制。外周给予吡啶斯的明(PD)可使下丘脑SRIH的释放最小化。
objective In animals, somatostatin (SRIH) and growth hormone (GH)‐releasing hormone (GHRH) increase feeding via a common neural mechanism. Furthermore, SRIH counteracts the suppressive action of corticotrophin‐releasing hormone (CRH) on food intake. Hypothetically, SRIH could be involved in the central feeding mechanism in anorexia nervosa (AN). Peripheral administration of pyridostigmine (PD) minimizes the release of hypothalamic SRIH.
脉动垂体腺苷酸环化酶激活多肽 (PACAP) 对灌注大鼠垂体细胞中促性腺激素分泌和亚基 mRNA 水平的影响。
DOI: 10.1016/0024-3205(95)00047-a
发表时间: 1995
期刊: Life sciences
影响因子: 6.1
作者:
Tsujii,T;Winters,SJ
通讯作者: Winters,SJ
DOI: 10.1210/jcem.78.6.8200929
发表时间: 1994
期刊: The Journal of clinical endocrinology and metabolism
影响因子: --
作者:
Schaefer,F;Veldhuis,JD;Stanhope,R;Jones,J;Scharer,K
通讯作者: Scharer,K